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Toxicological Effects of Simultaneous Exposure to Toluene and Noise on some Sexual and Stress Parameters in New Zealand White Rabbits
2023
Abouee-Mehrizi, Amirreza | Saed-Moucheshi, Shamseddin | Rasoulzadeh, Yahya | Mehdipour, Ahmad | Mohammadoghli-Reyhan, Fariba | Iraji, Zeynab | Alihemmati, Alireza | Shokoohi, Majid
Noise and toluene are among the numerous physical and chemical pollutants that can induce adverse effects on different body tissues and systems; nevertheless, most studies have only experimented the auditory changes induced by co-exposure to them. The present in-vivo study aimed to examine the endocrine effects of co-exposure to toluene and noise on the testes and adrenal glands. In this experimental study, 24 healthy male New Zealand White rabbits were used. The noise intensity was 100 dB (white noise) and the toluene concentration was 1000 ppm for two consecutive weeks. The luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone, cortisol and adrenocorticotropic hormone (ACTH) were measured using the enzyme-linked immunosorbent assay (ELISA) method. The hematoxylin and eosin stain method (H&E) was performed for the histopathological analysis. Comparing different parameters in different groups on post-exposure days was carried out using GEE (generalized estimating equations) method. The results indicated that noise and toluene increased cortisol, LH and FSH levels during different days after the exposure. Exposure to toluene and noise made vacuolization and reduction of primary spermatogonial cells in the testes. Moreover, lymphocyte infiltration, congestion, swelling and vacuolization were detected in adrenal glands through exposure to toluene and noise. Toluene and noise induced different destructive effects on the endocrine system. More studies are required to elucidate other endocrine changes induced by exposure to toluene and noise.
显示更多 [+] 显示较少 [-]Ecotoxicity of single and mixture of perfluoroalkyl substances (PFOS and PFOA) in soils to the earthworm Aporrectodea caliginosa
2023
Delor, L. | Louzon, M. | Pelosi, Céline | Michel, Eric | Maillet, G. | Carronnier, H. | Environnement Méditerranéen et Modélisation des Agro-Hydrosystèmes (EMMAH) ; Avignon Université (AU)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
International audience | Per and polyfluoroalkyl substances (PFAS) are persistent compounds that are massively used in industry, consumer goods and fire-fighting foams. Soil contamination by PFAS is a major environmental concern, and there is a lack of knowledge on both their ecotoxicological mechanisms and the concentrations that induce adverse effects especially to non-target organisms, particularly in the case of PFAS mixtures. This study contributes to filling these gaps by assessing and modelling the effects of PFAS (in single and in mixtures for PFOS and PFOA at different environmental doses) on juvenile endogeic earthworms of a common species in European soils (Aporrectodea caliginosa) at different levels of biological organization (sub-individual and individual). The results showed for the first time combined strong ecotoxicological effects of PFAS on earthworm survival, integumental integrity, growth, sexual maturity and on genomic stability notably with the induction of DNA breaks associated with no abnormal oxidative DNA-lesion levels. Our results demonstrated significant effects at 0.3 mg kg − 1 and additive effects in case of mixtures. ☆ This paper has been recommended for acceptance by Jiayin Dai.
显示更多 [+] 显示较少 [-]Avoidance behaviour and toxicological impact of sunscreens in the teleost Chelon auratus | Comportement d'évitement et impact toxicologique de crèmes solaires chez le téléoste Chelon Auratus
2023
Grimmelpont, Margot | Lefrançois, Christel | Panisset, Yannis | Jourdon, Guilhem | Receveur, Justine | Le Floch, Stéphane | Boudenne, Jean-Luc | Labille, Jérôme | Milinkovitch, Thomas | LIttoral ENvironnement et Sociétés (LIENSs) ; La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS) | Centre de documentation de recherche et d'expérimentations sur les pollutions accidentelles des eaux (Cedre) ; Cedre | Laboratoire Chimie de l'environnement (LCE) ; Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS) | Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE) ; Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | ANR-18-CE34-0012,CUTE,Contamination des eaux côtières aux filtres UV due à la fréquentation du littoral pendant les canicules: paramètres comportementaux et bioénergétiques permettant de mesurer les Effets et d'identifier des biomarqueurs d'alerte précoce(2018)
International audience | There is increasing evidence that sunscreen, more specifically the organic ultraviolet filters (O-UVFs), are toxic for aquatic organisms. In the present study, we simulated an environmental sunscreen exposure on the teleost fish, Chelon auratus. The first objective was to assess their spatial avoidance of sunscreen products. Our results showed that the fish did not avoid the contaminated area. Therefore, the second objective was to evaluate the toxicological impacts of such pollutants. At the individual level, O-UVFs increased the hepatosomatic index which suggests pathological alterations of the liver. At the cellular level, a significant increase of malondialdehyde was measured in the muscle of fish exposed to O-UVFs which suggests a failure of antioxidant defences and/or an excess 2 of reactive oxygen species. Although our study highlighted some of the toxicological effects due to O-UVFs contamination, further investigations are needed for a better understanding of the impact of these contaminants upon marine teleosts.
显示更多 [+] 显示较少 [-]Postnatal Exposure to A Low Dose of Imidacloprid: Oxidative Stress in Brain Without Affecting Learning and Behavior in Swiss Albino Mice
2023
A. Sharma, S. Gupta and M. Kaur
The neurotoxic effects of exposure to low levels of the pesticide imidacloprid (IMI) and the effect of curcumin are of current interest when exposure occurs during early development. Male weanlings of Swiss albino mice (21 days old) were given 1 mg.kg-1 body weight (1/130 of LD50 and 2 mg.kg-1 body weight (1/65 of LD50) of imidacloprid and Curcumin (100 mg/kg body wt.) by oral gavage from postnatal day 21 to postnatal day 60. Young adult offspring were studied for behavioral parameters and learning ability using open field and Morris water maze. After completing the behavioral test, brains were processed for acetylcholine esterase activity and antioxidant enzyme estimation. The level of lipid peroxidation and activity of catalase, superoxide dismutase, and glutathione were assayed. In the present study, parameters such as locomotor activities and cognitive skills were not affected compared to lower doses of imidacloprid in the open field and Morris water test. However, activities and levels of antioxidant enzymes such as catalase and lipid peroxidation were found to be altered. In contrast, superoxide dismutase, acetylcholine esterase activity, and glutathione remained unchanged compared to the control. This suggests that subchronic exposure to low doses of IMI can lead to significant alterations in the enzymes of antioxidant protective systems such as catalase and lipid peroxidation. Co-treatment with curcumin was able to restore the activities of the affected enzymes in comparison with the control.
显示更多 [+] 显示较少 [-]Effects of anthropogenic and environmental stressors on the current status of red mullet (Mullus barbatus L., 1758) populations inhabiting the Bulgarian Black Sea waters
2023
The red mullet (Mullus barbatus Linnaeus, 1758) is a keynote species for the Bulgarian Black Sea ecosystem and fisheries; nevertheless, existing knowledge on population status is very scarce. The present study was intended to assess the health status and adaptive potential of M. barbatus populations inhabiting the Bulgarian waters of the Black Sea. Our findings revealed that populations of M. barbatus are exposed to a variety of anthropogenic and environmental stressors. The species’ status was assessed using representative genetic, morphological, biochemical and chemical biomarkers from specimens obtained in the research area’s northern and southern regions. Based on mtDNA markers, genetic analysis revealed low haplotype and nucleotide diversity, typically observed in overexploited or “threatened” populations. Examining the morphology of the specimens revealed no discernible pattern of differentiation. Except for aluminium and chrome, metal and PAH concentrations in fish were below the regulatory thresholds. The specimens from the southern region ingested more microplastics than those from the northern region. The majority of specimens collected from the southern region also exhibited elevated levels of oxidative stress and decreased antioxidant defence, which can be interpreted as an early indication that they had reached the limits of their adaptive potential. Further research on the composite effects of the stressogenic environment on the Black Sea biota are critically needed, as well as the introduction of new indicators and thresholds at molecular and cellular levels for adequate monitoring of both the ecological state of the marine environment and its biota.
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