Air pollution exposure is a public health emergency, which attributes globally to an estimated seven million deaths on a yearly basis We are all exposed to air pollutants, varying from ambient air pollution hanging over cities to dust inside the home. It is a mixture of airborne particulate matter and gases that can be subdivided into three categories based on particle diameter. The smallest category called PM₀.₁ is the most abundant. A fraction of the particles included in this category might enter the blood stream spreading to other parts of the body. As air pollutants can enter the body via the lungs and gut, growing evidence links its exposure to gastrointestinal and respiratory impairments and diseases, like asthma, rhinitis, respiratory tract infections, Crohn's disease, ulcerative colitis, and abdominal pain. It has become evident that there exists a crosstalk between the respiratory and gastrointestinal tracts, commonly referred to as the gut-lung axis. Via microbial secretions, metabolites, immune mediators and lipid profiles, these two separate organ systems can influence each other. Well-known immunomodulators and gut health stimulators are probiotics, prebiotics, together called synbiotics. They might combat air pollution-induced systemic inflammation and oxidative stress by optimizing the microbiota composition and microbial metabolites, thereby stimulating anti-inflammatory pathways and strengthening mucosal and epithelial barriers. Although clinical studies investigating the role of probiotics, prebiotics, and synbiotics in an air pollution setting are lacking, these interventions show promising health promoting effects by affecting the gastrointestinal- and respiratory tract. This review summarizes the current data on how air pollution can affect the gut-lung axis and might impact gut and lung health. It will further elaborate on the potential role of probiotics, prebiotics and synbiotics on the gut-lung axis, and gut and lung health.

Environment can be affected by a variety of micropollutants. In this paper, we develop a system to assess the toxicity on an environmental sample, based on the expression of a nanoluciferase under the control of the STB5 promotor in a yeast. The STB5 gene encodes for a transcription factor involved in a pleiotropic drug resistance and in the oxidative stress response. The response of the modified yeast was assessed using 42 micropollutants belonging to different families (antibiotics, pain killers, hormones, plasticizers, pesticides, etc.). Among them, 26 induced an increase of the bioluminescence for concentration ranges from pg.L⁻¹ to ng.L⁻¹. Surprisingly, for concentrations higher than 100 ng.L⁻¹, no response can be observed, suggesting that other mechanisms are involved when the stress increases. Analyzing the different responses obtained, we highlighted six nonmonotonic types of responses. The type of response seems to be independent of the properties of the compounds (polarity, toxicology, molecular weight) and of their family. In conclusion, we highlighted that a cellular response exists for very low exposition to environmental concentration of micropollutants and that it was necessary to explore the cellular mechanisms involved at very low concentration to provide a better risk assessment.

Ibuprofen (IBU), as a commonly used non-steroidal anti-inflammatory drug (NSAID) and pharmaceutical and personal care product (PPCP), is frequently prescribed by doctors to relieve pain. It is widely released into environmental water and soil in the form of chiral enantiomers by the urination and defecation of humans or animals and by sewage discharge from wastewater treatment plants. This study focused on the alteration of metabolism in the adult zebrafish (Danio rerio) brain after exposure to R-(-)-/S-(+)-/rac-IBU at 5 μg L−1 for 28 days. A total of 45 potential biomarkers and related pathways, including amino acids and their derivatives, purine and its derivatives, nucleotides and other metabolites, were observed with untargeted metabolomics. To validate the metabolic disorders induced by IBU, 22 amino acids and 3 antioxidant enzymes were selected to be quantitated and determined using targeted metabolomics and enzyme assay. Stereoselective changes were observed in the 45 identified biomarkers from the untargeted metabolomics analysis. The 22 amino acids quantitated in targeted metabolomics and 3 antioxidant enzymes determined in enzyme assay also showed stereoselective changes after R-(-)-/S-(+)-/rac-IBU exposure. Results showed that even at a low concentration of R-(-)-/S-(+)-/rac-IBU, disorders in metabolism and antioxidant defense systems were still induced with stereoselectivity. Our study may enable a better understanding of the risks of chiral PPCPs in aquatic organisms in the environment.

A contingent valuation study is conducted in three locations in Turkey using a total of 1362 observations to elicit willingness to pay (WTP) to avoid the acute respiratory illness (three days of severe coughing and throat pain). This is the first research of this kind in Turkey, and also one of a few studies conducted in developing countries. Median WTPs are estimated as 65, 51, and 83 PPP-adjusted 2012 USD for Afsin-Elbistan, Kutahya-Tavsanli and Ankara, respectively. Income elasticities of WTP are derived as 0.8 for Afsin-Elbistan and tested statistically indifferent from 1.0 for Kutahya-Tavsanli, and Ankara, and are found to be greater than the cases in existing studies conducted both in developed and developing countries. We also find that 60 to 90 percent of WTP are devoted for avoiding pain and discomfort/restricted activity days, and much less weights are given for avoiding possible financial losses. As for the determinants of WTP, university graduates, those who have experienced coughing within one month, have spent out-of-pocket medical expenses and actually lost some part of their income due the last experienced minor symptoms are willing to pay more to avoid the future acute respiratory illness while women and the household using coal as the main source of home-heating are willing to pay less in one or more study areas. New air quality standard for PM10 (transition from 150 μg/m3 to 40 μg/m3 by 2019) causes the reductions in minor respiratory symptoms by 11, 8, and 4.4 per person, and the resulting welfare gains are calculated as 157 million, 123 million, and 1464 million PPP-adjusted 2012 USD for Afsin-Elbistan, Kutahya-Tavsanli and Ankara, respectively.

Open landfilling is a common practice of waste dumping in developing countries, generating a range of environmental and public health hazards. In this study, we determined the distribution, composition and exposure risk of the size-segregated fungal and bacterial bioaerosols in an open landfill site in Dehradun, India. Bioaerosol and particulate matter (PM) measurements were carried out using a six-stage viable Andersen Cascade Impactor and a Wide Range Aerosol Spectrometer, respectively. Pearson correlation analysis was used to determine the relation of bioaerosol concentration with meteorological parameters and PM. The mean concentration of fungal and bacterial aerosols was observed to be 4582.75 ± 1358.25 CFU/m3 and 3609.53 ± 1000.28 CFU/m3, respectively. The bioaerosol composition showed the predominance of potential pathogens including Aspergillus (25.42%), Penicillium (20.34%), Cladosporium (15.25%), Alternaria (13.56%); and gram-negative Bacillus (21.15%), Streptobacillus (17.31%), Coccus (13.46%). Also, an inhalation risk assessment was conducted for the age-specific predictions of bioaerosol and PM deposition in human airways using a multiple path particle dosimetry model. For bioaerosols, maximum submicron depositions in the pulmonary region were observed in adults, while for PM, in children and infants. Finally, to identify the bioaerosol exposure caused respiratory disorders, a questionnaire-based health survey was conducted among the exposed population around the landfill site. The chi-square test showed significantly higher respiratory complaints in females for cold, cough, chest pain and chest tightness than in males. This work highlights the role of bioaerosols and PM in human health disorders in occupational environments associated with waste management.

Balneotherapy (BT) is one of the most commonly used non-pharmacologic complementary therapies for different rheumatic diseases. Its beneficial properties probably derived from a combination of mechanical, thermal, and chemical effects, but the exact mechanism of action is not elucidated. This review aimed at summarizing the current knowledge about the effects of BT, and identifying its possible mechanism of action in different rheumatic diseases. Pubmed and Scopus were used to perform a search of the literature to extract articles including terms related to BT and rheumatic diseases published in the period from 2010 to 2021. We selected pre-clinical studies, randomized controlled trials, and clinical trials. The results of clinical studies confirmed the beneficial properties on different mediators and factors of inflammation, oxidative stress, cartilage metabolism, and humoral and cellular immune responses in patients affected by chronic degenerative musculoskeletal disorders. The data derived from OA and RA-induced murine models revealed the efficacy of different BT treatments in decreasing pain, inflammation, and improving mobility, as well as in reducing the expression of matrix-degrading enzymes and markers of oxidative stress damage. Different in vitro studies analyzed the potential effect of a mineral water, as a whole, or of a mineral element, demonstrating their anti-inflammatory, antioxidant, and chondroprotective properties in OA cartilage, synoviocytes and chondrocytes, and osteoblast and osteoclast cultures. The presented data are promising and confirm BT as an effective complementary approach in the management of several low-grade inflammation, degenerative, and stress-related pathologies, as rheumatic diseases.

Oil fume is always considered as a major source of indoor air pollution. This article aims to examine the effects of cooking oil fume as environmental pollution on the health of Chinese women by using the data obtained from China Labor force Dynamic Survey (CLDS). In order to estimate the effect of environmental pollution on the human health, we utilize probit model approach and baseline regression method. The results showed that oil fume has a significant negative impact on the health indicators of “physical pain, health impact on work and injury.” By conducting endogeneity analysis, our results show the robustness and indicate that oil fume has a robust effect on the women health. Heterogeneity analysis show that heavier oil fume has a negative impact on the subjective health of middle-aged and young women, while it has a significant negative impact on the objective health of middle-aged women. Analysis of the impact mechanism reveal that heavier oil fumes will reduce women’s sleep quality and will lead to the poorer health. Based on our study findings, this study proposes policy recommendations from the perspectives of the use of smoke extraction equipment, cooking methods, and sleep quality to reduce the negative impact of cooking fumes on women’s health.

Caustic chemicals are widely distributed in our environment. Exposure to caustic agents is a lifelong problem associated with severe tissue and mucous membrane injuries. In pediatrics, corrosive exposure is the most common cause of nonpharmaceutical exposure presenting to poison control centers. Therefore, this study evaluated the role of the Pediatric Early Warning System (PEWS) and Drooling Reluctance Oropharynx Others Leukocytosis (DROOL) scores as early in-hospital outcome predictors following corrosive ingestion. The current study was a two-center, retrospective, cross-sectional study carried out among pediatric patients diagnosed with acute caustic ingestion during the past 4 years. Most exposure occurred accidentally among boys (59.4%) living in rural areas (51.9%) of preschool age (50% were 2–4 years old). Residence, body temperature, respiratory rate, vomiting, skin and mucosal burns, retrosternal pain, respiratory distress, Oxygen (O2) saturation, Glasgow Coma Scale score, HCO₃ level, total bilirubin level, anemia, leukocytosis, and presence of free peritoneal fluid were significant predictors of esophageal injuries (p < 0.05). DROOL and PEWS scoring were the most significant predictors of esophageal injuries with worthy predictive power, where odds ratio (95% confidence interval (CI)) was 1.76 (0.97–3.17) and 0.47 (0.21–0.99) for PEWS and DROOL, respectively. At a cutoff of < 6.5, the DROOL score could predict esophageal injuries excellently, with AUC = 0.931; sensitivity, 91.7%; specificity, 72.5%; and overall accuracy, 91.3%. At a cutoff of > 6.5, PEWS could significantly predict unfavorable outcomes, with AUC = 0.893; sensitivity, 94.4%; specificity, 71.9%; and overall accuracy, 89.3%. However, PEWS better predicted the need for admittance to the intensive care unit (ICU). Pediatric Early Warning System (PEWS) and Drooling Reluctance Oropharynx Others Leukocytosis (DROOL) are potentially useful accurate scorings that could predict the esophageal injuries and ICU admission following corrosive ingestion in pediatrics.

In China, innovation plays an important role in achieving economic development with green growth, but innovation activities are inhibited by the spread of haze pollution (also called smog). Using panel data on 265 cities in China at the prefectural level from 2001 to 2018, this paper investigates the relationship between haze pollution and urban innovation. The conclusions are as follows. First, haze pollution has a significant inhibitory effect on urban innovation. After we consider endogeneity, eliminate extreme values, replace variables, and incorporate spatial correlation, we find that the negative impact of haze pollution on urban innovation still exists. Second, the channels through which haze pollution affects urban innovation are mainly attributed to production efficiency, willingness to consume, and entrepreneurial activity. Third, the inhibitory effect of haze pollution on innovation has a spatial spillover effect. Fourth, among the different regions in China, the most serious inhibitory effect of haze pollution on innovation is in the central region, while that of the eastern and western regions is insignificant. Moreover, across diverse Chinese cities, the significant inhibitory effects of haze pollution on innovation are mainly in cities that are abundant in natural resource. Accordingly, the efficient management of haze pollution is a critical prerequisite and effective guarantee for increasing urban innovation, such as promoting clean energy, strengthening technological innovation, and improving human capital.

The current state of the art for the use of natural ingredients for cancer therapy is by reviewing the publications and findings associated with cancer research with the employment of flavonoids. Cancer is the most furious disease making fear in the eyes of mankind. Though various treatment methods are prevalent, the patient’s choices are shifting from synthetic treatment strategy to the natural ones. The plant-based metabolites are used very often in our life as a food additive and also as a medicine for primary health care. The safety profile and its efficacy add on advantage for the incorporation of the natural products separately or in combination as a remedy for cancer. Flavonoids, the plant-based metabolites are proven for their anti-inflammatory, anti-oxidant, and anti-cancer properties. Their chemotherapeutic and chemosensitizing power had made it interesting for the researchers to dig more on the health benefits of the flavonoids and incorporating it in a holistic approach, with its natural benefits to relieve the pain and the symptoms of the patient suffering from various medical conditions. The predominant approach for the management of cancer is by following safe and effective treatment modality. In this review, we mentioned the benefits of the flavonoids for the management of various cancers and its potency as a chemotherapeutic agent and as the chemosensitizer. Our mother nature had given remedies to cure various diseases in both human beings and animals by it; we just need to find out the sources and access to them.