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Effects of the antineoplastic drug cyclophosphamide on the biochemical responses of the mussel Mytilus galloprovincialis under different temperatures 全文
2021
Queirós, Vanessa | Azeiteiro, Ulisses M. | Barata, Carlos | Santos, Juan Luis | Alonso, Esteban | Soares, Amadeu M.V.M. | Freitas, Rosa
Effects of the antineoplastic drug cyclophosphamide on the biochemical responses of the mussel Mytilus galloprovincialis under different temperatures 全文
2021
Queirós, Vanessa | Azeiteiro, Ulisses M. | Barata, Carlos | Santos, Juan Luis | Alonso, Esteban | Soares, Amadeu M.V.M. | Freitas, Rosa
Cyclophosphamide (CP) is an antineoplastic drug widely used in chemotherapy treatments with high consumption rates and that has been detected in the aquatic environment. After being released into the aquatic environment, CP may cause adverse effects on aquatic organisms since antineoplastics are well-known cytotoxic, genotoxic, mutagenic and teratogenic drugs. Moreover, predicted environmental changes, such as the temperature rising, may alter the impacts caused by CP on organisms. Thus, the present study aimed to assess the effects caused by CP chronic exposure in the mussel Mytilus galloprovincialis, under actual and predicted warming scenarios. Organisms were exposed for 28 days to different concentrations of CP (10, 100, 500 and 1000 ng/L) at control (17 ± 1.0 °C) and increased (21 ± 1.0 °C) temperatures. Biochemical responses related to metabolic capacity, energy reserves, oxidative stress and neurotoxicity were assessed. The results showed that the organisms were able to maintain their metabolic capacity under all exposure conditions. However, their antioxidant defense mechanisms were activated mostly at higher CP concentrations being able to prevent cellular damage, even under the warming scenario. Overall, the present findings suggest that temperature rise may not alter the impacts of CP towards M. galloprovincialis.
显示更多 [+] 显示较少 [-]Effects of the antineoplastic drug cyclophosphamide on the biochemical responses of the mussel Mytilus galloprovincialis under different temperatures 全文
2021
Queirós, Vanessa | Azeiteiro, Ulisses M | Barata Martí, Carlos | Santos, Juan Luis | Alonso, Esteban | Soares, Amadeu M. V. M. | Freitas, Rosa | 0000-0001-6426-0512 | 0000-0001-9704-1316 | 0000-0002-1647-9226 | 0000-0003-0879-9470 | Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
Cyclophosphamide (CP) is an antineoplastic drug widely used in chemotherapy treatments with high consumption rates and that has been detected in the aquatic environment. After being released into the aquatic environment, CP may cause adverse effects on aquatic organisms since antineoplastics are well-known cytotoxic, genotoxic, mutagenic and teratogenic drugs. Moreover, predicted environmental changes, such as the temperature rising, may alter the impacts caused by CP on organisms. Thus, the present study aimed to assess the effects caused by CP chronic exposure in the mussel Mytilus galloprovincialis, under actual and predicted warming scenarios. Organisms were exposed for 28 days to different concentrations of CP (10, 100, 500 and 1000 ng/L) at control (17 ± 1.0 °C) and increased (21 ± 1.0 °C) temperatures. Biochemical responses related to metabolic capacity, energy reserves, oxidative stress and neurotoxicity were assessed. The results showed that the organisms were able to maintain their metabolic capacity under all exposure conditions. However, their antioxidant defense mechanisms were activated mostly at higher CP concentrations being able to prevent cellular damage, even under the warming scenario. Overall, the present findings suggest that temperature rise may not alter the impacts of CP towards M. galloprovincialis. | Vanessa Queirós benefited from a PhD grant (PD/BD/150590/2020) given by the National Funds through the Portuguese Science Foundation (Fundação para a Ciência e a Tecnologia, FCT). Thanks are due for the financial support to CESAM (UIDB/50017/2020+UIDP/50017/2020). | Peer reviewed
显示更多 [+] 显示较少 [-]Octanol-water partition coefficient (logKow) dependent movement and time lagging of polycyclic aromatic hydrocarbons (PAHs) from emission sources to lake sediments: A case study of Taihu Lake, China 全文
2021
Wang, Weiwei | Qu, Xiaolei | Lin, Daohui | Yang, Kun
Understanding the movement of polycyclic aromatic hydrocarbons (PAHs) from emission sources to sediments is important for achieving long-term pollution control of PAHs in sediments. In this study, by exploring the correlation of individual PAHs concentrations (CPAHₛ) in Taihu Lake sediments reported in the past twenty years with their annual emissions (EPAHₛ) in the lake region, it was observed that mean concentrations of PAHs with low logKₒw (i.e., logKₒw≤4.00) in Taihu Lake sediments were correlated best with their emissions without lagging between the sediment sampling time and the PAHs emitting time. However, for PAHs with middle logKₒw (i.e., 4.00<logKₒw≤4.57) or high logKₒw (i.e., logKₒw>4.57), their mean concentrations in sediments were correlated best with the emissions of PAHs emitted 1 or 2 years before the sediment sampling time. The longer lagging time of PAHs with middle or high logKₒw from emission sources to lake sediments could be attributed to their retardation in soils and river sediments around the lake. Moreover, the retardation in soils and river sediments is dependent on PAHs logKₒw and degradation half-life, indicating the dependence of PAHs concentration in sediments on their environmental behaviors, including sorption and degradation. Kₒw dependent movement and the time lagging observed in Taihu Lake for PAHs from emission sources to sediments could be valuable for developing measures to control PAHs, especially for congeners with high logKₒw.
显示更多 [+] 显示较少 [-]Exploring nutrient and light limitation of algal production in a shallow turbid reservoir 全文
2021
Han, Yue | Aziz, Tarek N. | Del Giudice, Dario | Hall, Nathan S. | Obenour, Daniel R.
Harmful algal blooms are increasingly recognized as a threat to the integrity of freshwater reservoirs, which serve as water supplies, wildlife habitats, and recreational attractions. While algal growth and accumulation is controlled by many environmental factors, the relative importance of these factors is unclear, particularly for turbid eutrophic systems. Here we develop and compare two models that test the relative importance of vertical mixing, light, and nutrients for explaining chlorophyll-a variability in shallow (2–3 m) embayments of a eutrophic reservoir, Jordan Lake, North Carolina. One is a multiple linear regression (statistical) model and the other is a process-based (mechanistic) model. Both models are calibrated using a 15-year data record of chlorophyll-a concentration (2003–2018) for the seasonal period of cyanobacteria dominance (June–October). The mechanistic model includes a novel representation of vertical mixing and is calibrated in a Bayesian framework, which allows for data-driven inference of important process rates. Both models show that chlorophyll-a concentration is much more responsive to nutrient variability than mixing, light, or temperature. While both models explain approximately 60% of the variability in chlorophyll-a, the mechanistic model is more robust in cross-validation and provides a more comprehensive assessment of algal drivers. Overall, these models indicate that nutrient reductions, rather than changes in mixing or background turbidity, are critical to controlling cyanobacteria in a shallow eutrophic freshwater system.
显示更多 [+] 显示较少 [-]Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries 全文
2021
Julvez, Jordi | López-Vicente, Mónica | Warembourg, Charline | Maitre, Lea | Philippat, Claire | Gützkow, Kristine B. | Guxens, Monica | Evandt, Jorunn | Andrusaityte, Sandra | Burgaleta, Miguel | Casas, Maribel | Chatzi, Leda | de Castro, Montserrat | Donaire-González, David | Gražulevičienė, Regina | Hernandez-Ferrer, Carles | Heude, Barbara | Mceachan, Rosie | Mon-Williams, Mark | Nieuwenhuijsen, Mark | Robinson, Oliver | Sakhi, Amrit K. | Sebastián-Gallés, Núria | Slama, Remy | Sunyer, Jordi | Tamayo-Uria, Ibon | Thomsen, Cathrine | Urquiza, José | Vafeiadi, Marina | Wright, John | Basagaña, Xavier | Vrijheid, Martine
Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries 全文
2021
Julvez, Jordi | López-Vicente, Mónica | Warembourg, Charline | Maitre, Lea | Philippat, Claire | Gützkow, Kristine B. | Guxens, Monica | Evandt, Jorunn | Andrusaityte, Sandra | Burgaleta, Miguel | Casas, Maribel | Chatzi, Leda | de Castro, Montserrat | Donaire-González, David | Gražulevičienė, Regina | Hernandez-Ferrer, Carles | Heude, Barbara | Mceachan, Rosie | Mon-Williams, Mark | Nieuwenhuijsen, Mark | Robinson, Oliver | Sakhi, Amrit K. | Sebastián-Gallés, Núria | Slama, Remy | Sunyer, Jordi | Tamayo-Uria, Ibon | Thomsen, Cathrine | Urquiza, José | Vafeiadi, Marina | Wright, John | Basagaña, Xavier | Vrijheid, Martine
Epidemiological studies mostly focus on single environmental exposures. This study aims to systematically assess associations between a wide range of prenatal and childhood environmental exposures and cognition. The study sample included data of 1298 mother-child pairs, children were 6–11 years-old, from six European birth cohorts. We measured 87 exposures during pregnancy and 122 cross-sectionally during childhood, including air pollution, built environment, meteorology, natural spaces, traffic, noise, chemicals and life styles. The measured cognitive domains were fluid intelligence (Raven's Coloured Progressive Matrices test, CPM), attention (Attention Network Test, ANT) and working memory (N-Back task). We used two statistical approaches to assess associations between exposure and child cognition: the exposome-wide association study (ExWAS) considering each exposure independently, and the deletion-substitution-addition algorithm (DSA) considering all exposures simultaneously to build a final multiexposure model. Based on this multiexposure model that included the exposure variables selected by ExWAS and DSA models, child organic food intake was associated with higher fluid intelligence (CPM) scores (beta = 1.18; 95% CI = 0.50, 1.87) and higher working memory (N-Back) scores (0.23; 0.05, 0.41), and child fast food intake (−1.25; −2.10, −0.40), house crowding (−0.39; −0.62, −0.16), and child environmental tobacco smoke (ETS) (−0.89; −1.42, −0.35), were all associated with lower CPM scores. Indoor PM₂.₅ exposure was associated with lower N-Back scores (−0.09; −0.16, −0.02). Additional associations in the unexpected direction were found: Higher prenatal mercury levels, maternal alcohol consumption and child higher perfluorooctane sulfonic acid (PFOS) levels were associated with better cognitive performance; and higher green exposure during pregnancy with lower cognitive performance. This first comprehensive and systematic study of many prenatal and childhood environmental risk factors suggests that unfavourable child nutrition, family crowdedness and child indoor air pollution and ETS exposures adversely and cross-sectionally associate with cognitive function. Unexpected associations were also observed and maybe due to confounding and reverse causality.
显示更多 [+] 显示较少 [-]Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries 全文
2021
Julvez, Jordi | López-Vicente, Mónica | Warembourg, Charline | Maitre, Lea | Philippat, Claire | Gützkow, Kristine, B | Guxens, Monica | Evandt, Jorunn | Andrusaityte, Sandra | Burgaleta, Miguel | Casas, Maribel | Chatzi, Leda | de Castro, Montserrat | Donaire-González, David | Gražulevičienė, Regina | Hernandez-Ferrer, Carles | Heude, Barbara | Mceachan, Rosie | Mon-Williams, Mark | Nieuwenhuijsen, Mark | Robinson, Oliver | Sakhi, Amrit, K | Sebastian-Galles, Nuria | Slama, Remy | Sunyer, Jordi | Tamayo-Uria, Ibon | Thomsen, Cathrine | Urquiza, Jose | Vafeiadi, Marina | Wright, John | Basagaña, Xavier | Vrijheid, Martine | nstitut d’Investigaci´o Sanit`aria Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Reus (Tarragona), Catalonia, | Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal) | Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health (CIBERESP) | Universitat Pompeu Fabra [Barcelona] (UPF) | Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children’s Hospital, PO Box 2060, 3000 CB, Rotterdam, | Épidémiologie environnementale appliquée au développement et à la santé respiratoire/Environmental Epidemiology applied to Development and Respiratory Health (EPIDER (ENEDER) - IAB) ; Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB) ; Centre Hospitalier Universitaire [CHU Grenoble] (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Centre Hospitalier Universitaire [CHU Grenoble] (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA) | Norwegian Institute of Public Health [Oslo] (NIPH) | Vytauto Didziojo Universitetas (VDU), Kaunus, | Center for Brain and Cognition, Department of Technology, Universitat Pompeu Fabra, Roc Boronat 138, 08018, Barcelona, Catalonia, | Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion | Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, | Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Victoria, | Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques (CRESS (U1153 / UMR_A 1125)) ; Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford Royal Infirmary, Bradford | MRC Centre for Environment and Health, School of Public Health, Imperial College London, London | Division of Immunology and Immunotherapy, Cima Universidad de Navarra and “Instituto de Investigaci´on Sanitaria de Navarra (IdISNA)", Pamplona,
International audience
显示更多 [+] 显示较少 [-]Scenario analysis of vehicular emission abatement procedures in Xi’an, China 全文
2021
Song, Hui | Deng, Shun-Xi | Lu, Zhen-Zhen | Li, Jiang-Hao | Ba, Li-Meng | Wang, Jing-Fa | Sun, Zhi-Gang | Li, Guang-Hua | Jiang, Chao | Hao, Yan-Zhao
Vehicular emissions contribute significantly to air pollution, and the number of vehicles in use is continuing to rise. Policymakers thus need to formulate vehicular emission reduction policies to improve urban air-quality. This study used different vehicle control scenarios to predict the associated potential of mitigating carbon monoxide (CO), volatile organic compounds (VOCs), nitrogen oxide (NOₓ), particulate matter with an aerodynamic diameter less than 2.5 μm (PM₂.₅), and particulate matter with an aerodynamic diameter less than 10 μm (PM₁₀) in Xi’an China, in 2020 and 2025. One business-as-usual scenario and six control scenarios were established, and vehicular emission inventory was developed according to each scenario. The results revealed that eliminating high-emission vehicles and optimizing after-treatment devices would effectively reduce vehicular emissions. In addition, increasing the number of alternative fuel vehicles, restraining vehicle use, and restraining the growth of the vehicle population would all have certain effects on CO and VOCs emissions, but the effects would not be significant for NOx, PM₂.₅, and PM₁₀. The results also indicated that if all control measures were stringently applied together, emissions of CO, VOCs, NOₓ, PM₂.₅, and PM₁₀ would be reduced by 51.66%, 51.58%, 30.19%,71.12%, and 71.81% in 2020, and 53.55%, 51.44%, 19.09%, 54.88%, and 55.51%, in 2025, respectively.
显示更多 [+] 显示较少 [-]Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish 全文
2021
Jia, Pan-Pan | Junaid, Muhammad | Wen, Ping-Ping | Yang, Yi-Fan | Li, Wei-Guo | Yang, Xian'guang | Pei, De-Sheng
Numerous pieces of evidence documented the importance of gut microbiota in regulating human health and evaluating the toxicity of environmental pollutants, which are closely related to the host health in various aspects, including nutrition, energy translation, metabolism, pathogen resistance, and immune function. A variety of environmental factors can disrupt gut microbiota and their functions, and inevitably cause immune diseases, obesity and diabetes. However, deciphering the inner mechanisms involved in the functional interaction of gut microbes with host health is still needed extensive investigations. This review focused on the essential roles of intestinal microbes in host-related diseases and highlighted the development and applications of germ-free (GF) animal models, mainly zebrafish. Moreover, the generation, immunity characters, advantages and challenges of GF zebrafish models were also summarized. Importantly, the composition and isolation of zebrafish gut bacteria for further application and toxicity evaluation of aquatic environmental pollutants were also discussed. In conclusion, GF zebrafish play irreplaceable roles in understanding the potential functions and responses of customized microbiota towards human and environmental health implications.
显示更多 [+] 显示较少 [-]A comparative study of EOF and NMF analysis on downward trend of AOD over China from 2011 to 2019 全文
2021
Ma, Qiao | Zhang, Qianqian | Wang, Qingsong | Yuan, Xueliang | Yuan, Renxiao | Luo, Congwei
In recent decades China has experienced high-level PM₂.₅ pollution and then visible air quality improvement. To understand the air quality change from the perspective of aerosol optical depth (AOD), we adopted two statistical methods of Empirical Orthogonal Functions (EOF) and Non-negative Matrix Factorization (NMF) to AOD retrieved by MODIS over China and surrounding areas. Results showed that EOF and NMF identified the important factors influencing AOD over China from different angles: natural dusts controlled the seasonal variation with contribution of 42.4%, and anthropogenic emissions have larger contribution to AOD magnitude. To better observe the interannual variation of different sources, we removed seasonal cycles from original data and conducted EOF analysis on AOD monthly anomalies. Results showed that aerosols from anthropogenic sources had the greatest contribution (27%) to AOD anomaly variation and took an obvious downward trend, and natural dust was the second largest contributor with contribution of 17%. In the areas surrounding China, the eastward aerosol transport due to prevailing westerlies in spring significantly influenced the AOD variation over West Pacific with the largest contribution of 21%, whereas the aerosol transport from BTH region in winter had relative greater impact on the AOD magnitude. After removing seasonal cycles, biomass burning in South Asia became the most important influencing factor on AOD anomalies with contribution of 10%, as its interannual variability was largely affected by El Niño. Aerosol transport from BTH was the second largest contributor with contribution of 8% and showed a decreasing trend. This study showed that the downward trend of AOD over China since 2011 was dominated by aerosols from anthropogenic sources, which in a way confirmed the effectiveness of air pollution control policies.
显示更多 [+] 显示较少 [-]Cadmium pollution of soil-rice ecosystems in rice cultivation dominated regions in China: A review 全文
2021
Zou, Mengmeng | Zhou, Shenglu | Su, San | Jia, Zhenyi | Guo, Tianwei | Wang, Junxiao
Cd accumulation in paddy soils and its subsequent transfer to the food chain are widespread environmental issues, which has been extensively investigated in China. However, most studies focused on regional scales and these results may not be applicable to present the Cd contamination status in soil-rice ecosystems at a national scale. Therefore, based on collected data from China’s rice cultivation dominated regions, this study provides the Cd pollution level of paddy soils and rice grains in China. Results indicates that the Yangtze River basin, especially Hunan, required more attention due to the elevated Cd concentrations in soil-rice ecosystems. Moreover, this review summarizes the significant natural and anthropogenic sources, transport and accumulation mechanism as well as the influencing factors of Cd in soil-rice ecosystems. The wide occurrence of Cd contamination in paddy soils derived primarily from mining activities, intensive application of phosphates fertilizers and e-waste. Physicochemical characteristics of soil, soil microorganisms, temperature as well as the physiological features of rice plants all contribute to Cd accumulation in rice grains, which can be controlled to mitigate Cd accumulation in rice grains. This review will provide a scientific reference for Cd pollution control and management with respect to paddy field ecosystems in China and other countries.
显示更多 [+] 显示较少 [-]Toxic effects of NSAIDs in non-target species: A review from the perspective of the aquatic environment 全文
2021
Świacka, Klaudia | Michnowska, Alicja | Maculewicz, Jakub | Caban, Magda | Smolarz, Katarzyna
The presence of pharmaceuticals in the aquatic environment, both in marine and freshwater reservoirs, is a major concern of global environmental protection. Among the drugs that are most commonly used, NSAIDs tend to dominate. Currently, being aware of the problem caused by drug contamination, it is extremely important to evaluate the scale and the full spectrum of its consequences, from short-term to long-term effects. The influence on non-target aquatic animals can take place at many levels, and the effects can be seen both in behaviour and physiology, but also in genetic alterations or reproduction disorders, affecting the development of entire populations. This review summarises all the advances made to estimate the impact of NSAIDs on aquatic animals. Multicellular animals from all trophic levels, inhabiting both inland waters, seas and oceans, have been considered. Particular attention has been paid to chronic studies, conducted at low, environmentally-relevant concentrations, to estimate the real effects of the present pollution. The number of such studies has indeed increased in recent years, allowing for a better insight into the possible consequences of pharmaceutical pollution. It should be stressed, however, that our knowledge is still limited to a few model species, while there are many groups of organisms completely unexplored regarding the effects of drugs. Therefore, the main aim of this paper was to summarise the current state of knowledge on the toxicity of NSAIDs in aquatic animals, also identifying important gaps and major issues requiring further analysis.
显示更多 [+] 显示较少 [-]The abundance and characteristics of microplastics in surface water in the transboundary Ganges River 全文
2021
Napper, Imogen E. | Baroth, Anju | Barrett, Aaron C. | Bhola, Sunanda | Chowdhury, Gawsia W. | Davies, Bede F.R. | Duncan, Emily M. | Sumit Kumar, | Nelms, Sarah E. | Hasan Niloy, Md Nazmul | Nishat, Bushra | Maddalene, Taylor | Thompson, Richard C. | Koldewey, Heather
Microplastics (plastic < 5 mm in size) are now known to contaminate riverine systems but understanding about how their concentrations vary spatially and temporally is limited. This information is critical to help identify key sources and pathways of microplastic and develop management interventions. This study provides the first investigation of microplastic abundance, characteristics and temporal variation along the Ganges river; one of the most important catchments of South Asia. From 10 sites along a 2575 km stretch of the river, 20 water samples (3600 L in total) were filtered (60 samples each from pre- and post-monsoon season). Overall, 140 microplastic particles were identified, with higher concentrations found in the pre-monsoon (71.6%) than in post-monsoon (61.6%) samples. The majority of microplastics were fibres (91%) and the remaining were fragments (9%). We estimate that the Ganges, with the combined flows of the Brahmaputra and Meghna rivers (GBM), could release up to 1–3 billion (10⁹) microplastics into the Bay of Bengal (north-eastern portion of the Indian Ocean) every day. This research provides the first step in understanding microplastic contamination in the Ganges and its contribution to the oceanic microplastic load.
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