Relationships between urban network cities are shaped by demographic trends and the factors affecting it. This research, using two concepts of occupation distribution and urban network, seeks to study the effective factors in the occurrence and intensification of inequalities in the Isfahan city spatial network. In the same way, the changes and transformation of the Isfahan network (including 37 cities of Isfahan approved by City-Region Plan) are considered by employment indicators as well as distance between cities, using network mapping in social network analysis software (Gephi) in three periods: 1996, 2006, 2016. The research method is applied in terms of purpose and application. The data were gathered through library studies and review of documents. The data analysis method is also quantitative. For employment at any time, a separate network is mapped and analyzed. The results indicate that in Isfahan city network at the time of research, demographic changes in populated cities and low population centers do not directly correlate with the shift of employment in the urban network, while there is a direct relationship between cities with a moderate population and the flow of employment. In addition, the metropolis of Isfahan, with a significant percentage of facilities, resources, financial flows, political power, and population flows, does not have decent employment flows rank in urban network cities.