The present era is an era when rapid and amazing changes due to the rapid advancement of science and technology, political decisions by governments and other macro and micro factors arrive quickly which have a profound impact on the dominant trends. So, for the formulation of regional development scenarios in such era, realistic and systematic knowledge in the strategic area of ​​ planning seems to be essential. Using developmental approach and applying systems theory, the researcher in this study aimed to evaluate and analyze the development strategic variables of Mazandaran province as the main variables of scenario planning for regional development in horizon 1410. The methodology of this study is structural analysis. It is a qualitative research in terms of nature of the data, and a survey and documentary one in terms of methods of data collection. Cross analysis are used to analyze data by use of MICMAC software. The results indicate that the key and strategic variables of Mazandaran province development in Horizon 1410 includes: "the way of country’s macro management ," "inflation," "the way of managing the province", "Research & Development (R & D)", "level of IT (information technology)", "population", and finally "inter-institutional cooperation ". Meanwhile, the key capabilities and the priorities of the development of the province in Horizon 1410 include: "Crops", "gardens and nursery ", "aquaculture", "special economic zone of Amirabad", "tourism", "Fereidoon'kenar Port", "AmirAbad Port ".