This study was conducted to determine the effects of use organo-mineral fertilizers and poultry manure on yield and quality of seed tubers different potatoes varieties (Solanum tuberosum L.). The study was designed in three replicated completely randomized block factorial design with eight potato cultivars (Madaline, Provento, Marfona, Agata, Arizona, Mustang, Rumba and Saviola) and including three different fertilizer as Hexaferm organo-mineral (%20 organics, 8-21-0+Zn), compost (1 t da-1) and fermented poultry manure (1 t da-1). In order to determine the effect of fertilizer forms on the yield and quality characteristics of different varieties of potatoes were examined features like output time of the tuber, output rates, plant height, stem number per hill, tuber yield per hill, total tuber yield, cracks tuber yield, dry matter content, starch content and specific gravity. Used fertilizers have no significant effect on output time of the tuber, output rates, plant height, stem number per hill, total tuber yield, dry matter content, starch content and specific gravity of varieties. The difference observed in terms of output time of the tuber, output rates, plant height, stem number per hill between the varieties was insignificant. The difference between the average tuber yield per hill, total tuber yield, cracks tuber yield, dry matter content, starch content and specific gravity of varieties were significant. Similarly, the fertilizers had a significant effect on the average tuber yield per hill of varieties . The significant interactions were found on traits average tuber yield per hill and average specific gravity between Fertilizer x Varieties. As a result, considered economically the fermented and compost poultry manure can be used instead of organo-mineral fertilizers in the production of seed potatoes.