Ethiopia’s agricultural production has been challenged by waterlogging, salinity, acidity, parasitic weed, and irrigation scheduling problems which has resulted in lower yields than the potential. Waterlogging is the main drainage problem in the small scale irrigation schemes in the Vertisols dominated highland areas while salinity and salinization is a common phenomenon in the large and medium scale irrigation schemes located in the lowlands of the country’s major river basins with predominantly salt affected soils. Soil acidity and associated low nutrient availability is one of the constraints to crop production on acid soils. Lime requirement for crops grown on acid soils is determined by the quality of liming material, status of soil fertility, crop species and varieties, crop management practices, and economic considerations. A considerable loss in growth and yield of many food and fodder crops is caused by root-parasitic flowering plants. Globally, Striga and Orobanche have a greater impact on human welfare than any other parasitic angiosperms because their hosts are subsistence crops in areas marginal for agriculture. In irrigated agriculture, efficient water management is an important element. Such practices can help bust sustainable production and maintain farm profitability in which there is limited water resource.