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Distribution of sulfamethoxazole in body fluids of buffaloes (Bubalus bubalis)
1989
Srivastana, K.A. | Rampal, S. (Punjab Agricultural Univ., Ladhaina (India). College of Veterinary Science, Department of pharmacology)
The distribution and urinary excretion of sulfamethoxazole were investigated in healthy buffalo calves. After a single iv dose (100 mg/kg), the blood level peaked at 103.8+-4.3 ug ml-1 at 15 min and declined to 12 ug ml-1 at 24 h. The minimum inhibitory concentration of drug (25 ug ml-1) was maintained up to 12 h. The extent of penetration of sulfamethoxazole in erythrocytes was calculated to be 19-35 %. Fulfamethoxazole rapidly distributed in cerebrospinal fluid (CSF) and interstitial fluid, with concentrations of 8.1-40.7 ug/ml and 11.8-64.7 ug/ml from 15 to 720 min of administration, respectively.
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