We examined the hypothesis that histidine is a regulator of short-term food and water intake in rats and that this control is through histidine's action as a precursor for histamine. The primary objectives were to measure food and water intake after histidine monohydrochloride monohydrate (His-HCl) given by intragastric (IG) and intraperitoneal (IP) routes of administration and to measure feeding and drinking responses to histidine when given after blockade of the histaminergic pathway by chlorpheniramine (CPA) and alpha-fluoromethylhistidine (FMH). Eight experiments were conducted using a back-to-back design. Rats were given treatment by IP or IG administration, and food and water intake was measured during time periods of 0-1, 1-2, 2-3 and 3-14 h. Histidine consistently reduced food intake with the sensitivity to IP much greater than to the IG route. The effect of histidine given by IP or IG on water intake was similar, generally causing an increase at least in the first hour. Histidine's action was not accounted for by its energy, pH or nitrogen content. Because FMH, which blocks the enzyme converting histidine to histamine, partially reversed the effect of histidine on food and water intake, those results support the hypothesis that histidine regulates food and water intake, at least in part, through its precursor control of histamine.

There has been developed a two-stage method for cooling jars with preserved food after sterilization. The first stage comprises cooling preserves up to t 75-80 deg. C in the air flow, the air velocities being 2.75, 3.7, 4.8, and 5.8 m/sec. The time of cooling reduced as the air velocity increases to be 11, 9, 8.5 and 8 min, respectively. The average speed of cooling gradually increases from 1.82 deg. C/min to 2.5 deg. C/min. The second stage comprises continuing cooling to apply a water film of 60-65 deg. C to the jar surface at 5-10 sec interval. During the process a jar is with a certain frequency is overturned down from the bottom to the cap. The average speed of cooling product is 3.33 deg. C/min at cooling air velocity of 2.75 m/sec and it is gradually increasing to reach 5.4 deg. C/min. Experimentally range of optimum cooling air velocities has been determined to be 4.8-5.8 m/sec, cooling time being decreased by 0.6 min only. A mathematical model has been has been developed describing the two-stage air and water vaporizing cooling time of stewed fruit jars depending on some factors. Relative error in comparing target values with experimental values did not exceed 8%. The developed method is recommended to be used at food canning industry enterprises and for designing continuously operating devices. | Разработан двухэтапный способ охлаждения банок с консервированными продуктами после стерилизации. На первом этапе (до t 75-80 град. С) охлаждение консервов производят в потоке атмосферного воздуха при различных скоростях охлаждающего воздуха – 2,75; 3,7; 4,8 и 5,8 м/с. Продолжительность охлаждения с увеличением скорости охлаждающего воздуха снижается и составляет соответственно 11,0; 9,0; 8,5 и 8,0 мин. При этом средняя скорость охлаждения продукта постепенно увеличивается с 1,82 град. С/м до 2,5 град. С/мин. На втором этапе охлаждение продолжается с нанесением на поверхность банки водяной пленки температурой 60-65 град. С с интервалом 5-10 с, при этом в процессе охлаждения банку с определенной частотой переворачивают с донышка на крышку. Средняя скорость охлаждения продукта составляет 3,33 град. С/мин при скорости охлаждающего воздуха 2,75 м/с и постепенно увеличивается, достигая 5,4 град. С/мин. Экспериментально определен интервал оптимальных скоростей охлаждающего воздуха (4,8-5,8 м/с), при котором продолжительность процесса охлаждения сокращается всего на 0,6 мин. Составлена математическая модель, описывающая продолжительность двухэтапного воздушно-водоиспарительного охлаждения банок с компотами в зависимости от ряда факторов. Относительная погрешность при сопоставлении расчетных значений с опытными не превышала 8%. Разработанный способ рекомендуется для применения на предприятиях консервной промышленности и при проектировании аппаратов непрерывного действия.