A study of 20 healthy young male volunteers confirmed the existence of a quantitative and temporal relationship between food and fluid intake, and assessed the effects of fluid restriction on food acceptability and intake under scheduled eating conditions. Fluid restriction and thirst were significantly correlated with a reduction of food intake. Possible explanations of the relation between food and fluid intake are discussed.

Two healthy men were evaluated before and after a 56 day raft voyage to determine endocrine and metabolic status immediately after and during the recovery phase after long term caloric, protein, and water deprivation. Daily intake during the trip consisted of no protein, 300 ml water, and for the first 40 days, 300 Kcal glucose. The subjects lost weight from 84.1 to 58.1 and 78.3 to 57.7 kg, respectively. Other variations were measured including rate of excretion, diurnal patterns, serum testosterone levels, plasma insulin levels, serum glucose concentrations, triglyceride content, liver function, fat and xylsoe absorption, and renal function.

The proliferation of food, feed and biofuels demands promises to increase pressure on water competition and stress, particularly for Thailand, which has a large agricultural base. This study assesses the water footprint of ten staple crops grown in different regions across the country and evaluates the impact of crop water use in different regions/watersheds by the water stress index and the indication of water deprivation potential. The ten crops include major rice, second rice, maize, soybean, mungbean, peanut, cassava, sugarcane, pineapple and oil palm. The water stress index of the 25 major watersheds in Thailand has been evaluated. The results show that there are high variations of crop water requirements grown in different regions due to many factors. However, based on the current cropping systems, the Northeastern region has the highest water requirement for both green water (or rain water) and blue water (or irrigation water). Rice (paddy) farming requires the highest amount of irrigation water, i.e., around 10,489 million m3/year followed by the maize, sugarcane, oil palm and cassava. Major rice cultivation induces the highest water deprivation, i.e., 1862 million m3H₂Oeq/year; followed by sugarcane, second rice and cassava. The watersheds that have high risk on water competition due to increase in production of the ten crops considered are the Mun, Chi and Chao Phraya watersheds. The main contribution is from the second rice cultivation. Recommendations have been proposed for sustainable crops production in the future.

Investigations were carried out on the effects of water and food deprivation on the milk yield, body weight, blood composition and urine volume of lactating Nubian goats. The animals survived 4 days of deprivation of either food or both food and water, but these treatments resulted in about 10 per cent loss in body weight, 85 per cent drop in urine volume, and cessation of milk production, but no significant changes in packed cell volume, serum sodium, potassium and total protein. The change in body weight could be reversed within 1 day, but the initial milk yield was not resumed during the 2 weeks immediately following restoration of food and water.

In order to provide information on the state of hydration of broilers during marketing, 7-week-old Ross broilers of mixed sex were kept at 17 or 23 degrees C and deprived of food, or food and water, for 24 h. Measurements were made of live weight, carcass weight, muscle moisture, packed cell volume, plasma glucose, corticosterone, total protein, osmolality and sodium. There was a decrease in live weight, carcass weight, plasma glucose and plasma total protein, and an increase in packed cell volume and corticosterone, in birds deprived of food, or food and water. Muscle moisture increased in birds deprived of food and decreased in birds deprived of food and water. Osmolality decreased in birds deprived of food, the decrease being greater in birds at 23 degrees C. Plasma sodium levels were higher in birds kept at 23 degrees C and increased only in birds deprived of food and water at 23 degrees C.

This study investigated the effect of food or water deprivation on the pharmacokinetics of paracetamol in 30 Holstein-Friesian preruminant calves (10 controls, 10 food withheld and 10 water-deprived) aged 24–25 days. Control calves were given paracetamol at 24–25 days and again at 28–29 days of age. In the food withheld and water-deprived calves paracetamol studies were performed before and after 4 days of food or water deprivation. In the control group there were no significant differences in pharmacokinetic parameters for paracetamol in 24–25 and 28–29-day-old calves. Witholding food for 4 days was associated with an increase in the mean residence time (MRT) of paracetamol (P < 0.01). When food was withheld total body clearance (ClB) of paracetamol was significantly decreased (P < 0.05). The volume of distribution (V(ss)) was not significantly altered. Similarly, water deprivation was associated with a significant increase in MRT and significant decrease in ClB of paracetamol (P < 0.01). The V(ss) was not significantly altered. Food or water deprivation also influenced the formation of major metabolites (glucuronide and sulphate) of paracetamol. It is concluded that food or water deprivation may impair the elimination drugs that undergo metabolism by UDP-glucuronyltransferase and sulphotransferase in cattle.