Pesticides have been used for a long time in agriculture to prevent the growth of undesired organisms. However, depending on the type of production (i.e., conventional, organic, and regenerative), they might not be applied. Adequate types and uses of pesticides should not cause any damage to any non-target species or environments due to the exposure to it, especially if all farming operations have been done properly. Reversely, when pesticides are applied in inappropriate time, amount or technique, they may cause several impacts, among which is water contamination. Brazil stands out worldwide for its agricultural potential, but it is exposed to risks concerning the water supply security to its population. The current study is a comparison of the Maximum Permissible Concentrations (MPC) for pesticides in potable water supply in Brazil with the values set in the United States, Canada, European Union countries, Japan, and the guidelines issued by the World Health Organization. The regulations of each country were used, as well as the trading, consumption and agricultural production data. The Brazilian regulation is the one accounting for the largest number of pesticides. However, their MPC is 5,000 times more permissible than that from the European Union for the herbicide known as glyphosate, 300 times than that for 2,4-d and 20 times than that for atrazine. Finally, it was possible to observe the relevance of revising the regulation and public policies in place to minimize the indiscriminate use of pesticides in Brazil and adapt these compounds to the standards in a global level.