The effect of pralidoxime chloride upon the action of vasoactive drugs (adrenomimetics and cholinomimetics)
1987
Zivanov, D. | Jezdimirovic, M. (Faculty of Veterinary Medicine, Beograd (Yugoslavia))
Experiments conducted on rats showed that pralidoxime chloride (2-PAM C1) administered intravenously in a dose of 15 mg/kg hardly affected the hypotensive effect of isoprenaline (2 mg/kg) and the hypertensive effects of noradrenaline and adrenaline (2.6 mg/kg and 18 mg/kg respectively). It was only the effect of adrenaline in a dose of 6 mg/kg that was significantly shortened. On the other hand, 2-PAM C1 caused a significant decrease of both the intensity and duration of the oxedrine's (2 mg/kg) hypertensive effect. 2-PAM C1 administered in a dose of 15 mg/kg slightly changed the hypotensive effect of carbochol. However, a dose of 45 mg/kg of 2-PAM caused a statistically significant decrease of the carbachol's hypotensive effect in the trials with smaller doses of this cholinomimetic. Still, neither that dose did influence significantly the hypotensive effect of acetylcholine.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
المعلومات البيبليوغرافية
تم تزويد هذا السجل من قبل Unassigned data from Yugoslavia