The effect of pralidoxime chloride upon the action of vasoactive drugs (adrenomimetics and cholinomimetics)
1987
Zivanov, D. | Jezdimirovic, M. (Faculty of Veterinary Medicine, Beograd (Yugoslavia))
Experiments conducted on rats showed that pralidoxime chloride (2-PAM C1) administered intravenously in a dose of 15 mg/kg hardly affected the hypotensive effect of isoprenaline (2 mg/kg) and the hypertensive effects of noradrenaline and adrenaline (2.6 mg/kg and 18 mg/kg respectively). It was only the effect of adrenaline in a dose of 6 mg/kg that was significantly shortened. On the other hand, 2-PAM C1 caused a significant decrease of both the intensity and duration of the oxedrine's (2 mg/kg) hypertensive effect. 2-PAM C1 administered in a dose of 15 mg/kg slightly changed the hypotensive effect of carbochol. However, a dose of 45 mg/kg of 2-PAM caused a statistically significant decrease of the carbachol's hypotensive effect in the trials with smaller doses of this cholinomimetic. Still, neither that dose did influence significantly the hypotensive effect of acetylcholine.
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