Bisphenol A mediated effects on innate immunity in freshwater teleost spotted snakehead Channa punctatus murrel
2018
Pandey, Mamta | Ghorai, SomaM. | Rai, Umesh
The present study aimed to investigate the direct effect of endocrine disruptor, bisphenol A (BPA), on phagocytosis, superoxide production and nitric oxide release by splenic phagocytes of the teleost Channa punctatus. BPA is a xenoestrogen and has been identified as potent exotoxic agent in aquatic ecosystems. Our observations indicated differential immunomodulatory effects on teleost phagocyte activities. Fish splenic phagocytes were incubated in RPMI-1640 culture medium for 16 h with either BPA or E₂ at varying concentrations ranging from 10⁻⁹ M to 10⁻⁶ M. Incubation with both BPA and E₂ showed a significant (P < 0.05) increase in superoxide production. Conversely, phagocytosis was depressed at all concentrations, while NO release was significantly less (P < 0.05) at 10⁻⁸ M to 10⁻⁷ M concentrations of BPA and 10⁻⁹ M to 10⁻⁶ M concentrations of E₂. The present study thus indicated that BPA can modulate innate immune responses in teleost C. punctatus by altering fish immune cell activities, thereby affecting general fitness of the entire population.
اظهر المزيد [+] اقل [-]الكلمات المفتاحية الخاصة بالمكنز الزراعي (أجروفوك)
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