Bisphenol A mediated effects on innate immunity in freshwater teleost spotted snakehead Channa punctatus murrel
2018
Pandey, Mamta | Ghorai, SomaM. | Rai, Umesh
The present study aimed to investigate the direct effect of endocrine disruptor, bisphenol A (BPA), on phagocytosis, superoxide production and nitric oxide release by splenic phagocytes of the teleost Channa punctatus. BPA is a xenoestrogen and has been identified as potent exotoxic agent in aquatic ecosystems. Our observations indicated differential immunomodulatory effects on teleost phagocyte activities. Fish splenic phagocytes were incubated in RPMI-1640 culture medium for 16 h with either BPA or E₂ at varying concentrations ranging from 10⁻⁹ M to 10⁻⁶ M. Incubation with both BPA and E₂ showed a significant (P < 0.05) increase in superoxide production. Conversely, phagocytosis was depressed at all concentrations, while NO release was significantly less (P < 0.05) at 10⁻⁸ M to 10⁻⁷ M concentrations of BPA and 10⁻⁹ M to 10⁻⁶ M concentrations of E₂. The present study thus indicated that BPA can modulate innate immune responses in teleost C. punctatus by altering fish immune cell activities, thereby affecting general fitness of the entire population.
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