MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming
2018
Prieto Martínez, Javier | Seo, Arnold Y. | León Rodríguez, Marian | Santacatterina, Fulvio | Torresano, Laura | Palomino-Schätzlein, Martina | Giménez, Karen | Vallet-Sánchez, Azahara | Ponsoda i Martí, Xavier | Pineda Lucena, Antonio | Cuezva, José M. | Lippincott-Schwartz, Jennifer | Torres Ibáñez, José Manuel
Cell reprogramming is thought to be associated with a full metabolic switch from an oxidative- to a glycolytic-based metabolism. However, neither the dynamics nor the factors controlling this metabolic switch are fully understood. By using cellular, biochemical, protein array, metabolomic, and respirometry analyses, we found that c-MYC establishes a robust bivalent energetics program early in cell reprogramming. Cells prone to undergo reprogramming exhibit high mitochondrial membrane potential and display a hybrid metabolism. We conclude that MYC proteins orchestrate a rewiring of somatic cell metabolism early in cell reprogramming, whereby somatic cells acquire the phenotypic plasticity necessary for their transition to pluripotency in response to either intrinsic or external cues.
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