Total Synthesis of Paecilospirone.
2011
Yuen, TY | Yang, SH | Brimble, MA
In 2000, Namikoshi et al. reported the isolation and structuralelucidation of a novel [5,6]-bisbenzannulated spiroacetal[1]from the marine fungus Paecilomyces sp.[2]This uniquespiro[chroman-2,1’(3’H)-isobenzofuran] derivative was identified as a potential antimitotic agent (20 % inhibition at50 mm) using an assay screening for microtubule assemblyinhibitors and was subsequently named paecilospirone (1).
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