SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury
2021
Meng-Li Wu | Feng-Liang Liu | Jing Sun | Xin Li | Xiao-Yan He | Hong-Yi Zheng | Yan-Heng Zhou | Qihong Yan | Ling Chen | Guo-Ying Yu | Junbiao Chang | Xia Jin | Jincun Zhao | Xin-Wen Chen | Yong-Tang Zheng | Jian-Hua Wang
A schematic illustration of SARS-CoV-2 triggers MC rapid degranulation to induce alveolar epithelial inflammation and lung injury. SARS-CoV-2 triggers an immediate mast cell (MC) degranulation, which initiates the alveolar epithelial inflammation and disrupts the tight junction. MC stabilizers that block degranulation reduce virus-induced lung inflammation and injury.
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