Reduction with tris(2-carboxyethyl)phosphine (TCEP) enables the use of an S-sulphonate protecting group for thiol-mediated bioconjugation
2014
Maret, Barbara | Regnier, Thomas | Rossi, Jean-Christophe | Garrelly, Laurent | Vial, Laurent | Robert, Pascal
Herein, we demonstrate the effectiveness of the water-friendly S-sulphonate group as an alternative to traditional thiol protecting groups for subsequent deprotection–bioconjugation reactions, under conditions that are compatible with the use of biochemical samples.
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