New ingol-type diterpenes from the latex of Euphorbia resinifera

Wang, Shuyun; Li, Guo-Yu; Zhang, Ke; Wang, Hang-Yu; Liang, Hong-Gang; Huang, Chao; Huang, Jian; Wang, Jin-Hui; Yang, Bao-Feng

New ingol-type diterpenes from the latex of Euphorbia resinifera

2019

Two new ingol-type diterpenes, euphoresins A–B (1–2), have been isolated from the methanol extract of Euphorbium, the latex of Euphorbia resinifera Berg. Their structures were established on the basis of extensive analyses of their HR-ESI-MS, IR, UV, 1D, and 2D NMR spectra. The absolute configurations were confirmed by Mosher’s method and circular dichroism (CD) analyses. The two compounds were tested for their cytotoxic activities against MCF-7, U937, and C6 cancer cell lines, but they both exhibited little cytotoxic effect.

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AGROVOC Keywords

cell lines cytotoxicity diterpenoids euphorbia latex methanol neoplasms nuclear magnetic resonance spectroscopy

Bibliographic information

Published in

Journal of Asian natural products research

ISSN 1477-2213

Publisher

New York : Springer-Verlag

Other Subjects

Circular dichroism spectroscopy; Neoplasm cells; Euphorbium; Ingol-type diterpenes

Language

English

Note

This work received the support of Key Projects of the National Science and Technology Pillar Program (2012BAI30B02) and National Science and Technology Major Projects for New Drug Development (2018ZX09305005).

Type

Journal Article; Text

In AGRIS since: 2024-02-27

Format: MODS

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Links

DOI DOI http://dx.doi.org/10.1080/10286020.2018.1498084

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