New ingol-type diterpenes from the latex of Euphorbia resinifera

Wang, Shuyun; Li, Guo-Yu; Zhang, Ke; Wang, Hang-Yu; Liang, Hong-Gang; Huang, Chao; Huang, Jian; Wang, Jin-Hui; Yang, Bao-Feng

New ingol-type diterpenes from the latex of Euphorbia resinifera

2019

Two new ingol-type diterpenes, euphoresins A–B (1–2), have been isolated from the methanol extract of Euphorbium, the latex of Euphorbia resinifera Berg. Their structures were established on the basis of extensive analyses of their HR-ESI-MS, IR, UV, 1D, and 2D NMR spectra. The absolute configurations were confirmed by Mosher’s method and circular dichroism (CD) analyses. The two compounds were tested for their cytotoxic activities against MCF-7, U937, and C6 cancer cell lines, but they both exhibited little cytotoxic effect.

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Ключевые слова АГРОВОК

cell lines cytotoxicity diterpenoids euphorbia latex methanol neoplasms nuclear magnetic resonance spectroscopy

Библиографическая информация

Опубликовано в

Journal of Asian natural products research

ISSN 1477-2213

Издатель

New York : Springer-Verlag

Другие темы

Circular dichroism spectroscopy; Neoplasm cells; Euphorbium; Ingol-type diterpenes

Язык

Английский

Примечание

This work received the support of Key Projects of the National Science and Technology Pillar Program (2012BAI30B02) and National Science and Technology Major Projects for New Drug Development (2018ZX09305005).

Тип

Journal Article; Text

В АГРИСе с: 2024-02-27

Формат: MODS

Поставщик данных

Эту запись предоставил National Agricultural Library

Откройте коллекцию этого поставщика данных в AGRIS

Ссылки

DOI DOI http://dx.doi.org/10.1080/10286020.2018.1498084

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