Design, synthesis, and anticancer activities of new compounds bearing the quinone–pyran–lactone tricyclic pharmacophore
2015
Jiang, Xue | Wang, Meining | Song, Shanshan | Xu, Youjun | Miao, Zehong | Zhang, Ao
A simple and more effective four-step synthesis of the tricyclic quinone–pyran–lactone skeleton was developed. Subsequent structural modification led to several series of derivatives. Regio- and diastereo-characteristics of these compounds were elucidated, and their antitumor activities against several cancer cells were investigated.
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