Enantioselective Intermolecular Enamide–Aldehyde Cross-Coupling Catalyzed by Chiral N-Heterocyclic Carbenes
2016
Wu, Jicheng | Zhao, Changgui | Wang, Jian
The unprecedented N-heterocyclic carbene (NHC)-catalyzed intermolecular cross-coupling of enamides and aldehydes is described. Upon exposure of enamides to aldehydes in the presence of a NHC catalyst, catalytic C–C bond formation occurs, providing highly enantioselective N-protected amines, bearing a quaternary carbon center, in good yields and with high enantioselectivities.
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