Asymmetric iridium-catalyzed hydrogenation of 2-methylindole using phosphite ligands
2014
Lyubimov, Sergey E. | Ozolin, Dmitry V. | Davankov, Vadim A.
The iridium-catalyzed asymmetric hydrogenation of 2-methylindole using monodentate phosphites and amidophosphites as ligands was examined. The use of iodine as the additive resulted in increased enantioselectivity and conversion in the iridium-catalyzed hydrogenation of 2-methylindole. Full conversion and up to 80% ee were obtained with a catalyst based on a phosphite ligand.
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