Synthesis of polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth
2013
Thévenin, Marion | Thoret, Sylviane | Grellier, Philippe | Dubois, Joëlle
A series of polysubstituted benzofuran derivatives was easily and rapidly prepared using a tandem Sonogashira coupling/cyclization reaction. Subsequent acylation afforded a small library of 39 new compounds that were assayed in cellulo on Plasmodium falciparum and Trypanosoma brucei parasites. Some of them exhibited good inhibitory activity on T. brucei proliferation.
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