Introduction of several groups to the D-ring of grayanotoxin

Iwasa, J. . Faculty of Agriculture; Kawanishi, T.; Handa, S.; Kamano, H.; Yamamoto, S.; Okamoto, M.; Takeda, N.; Nakamura, M.; Masutani, T.; Shiro, M.; Nakajima, S.; Baba, N.; Seyama, I.

Introduction of several groups to the D-ring of grayanotoxin

1992

Grayanotoxin (GTX), one of the lipid-soluble Na+ channel openers, contains four rings (A, B, C and D) and the chemical groups essential for the pharmacological action are located on the A- and B-rings. To study the biological significance of functional groups on the D-ring, 51 new derivatives were prepared from alpha-dihydro GTX-II. These new compounds and the previously prepared GTXs were directly applied to the intracellular phase of internally perfused squid giant axons

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AGROVOC Keywords

ericaceae structure chimique

Bibliographic information

Published in

Scientific Reports of the Faculty of Agriculture - Okayama University (Japan)

Issue 79 ISSN 0474-0254

Pagination

pp. 1-35

Other Subjects

Compuestos organicos; Synthese chimique; Sintesis quimica; Compose organique; Estructura quimica

Language

English

Note

Summaries (En, Ja)

1 table; 7 fig.; 22 ref.

Type

Summary

In AGRIS since: 1994-08-15

Format: AGRIS AP

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Introduction of several groups to the D-ring of grayanotoxin

1992

AGROVOC Keywords

Bibliographic information