THE INFLUENCE OF ANTITUMOR DRUG CIS-DDP ON PHYSICOCHEMICAL PROPERTIES OF DNA
2023
Sargsyan, Sh. A. | Antonyan, A. P. | Vardevanyan, P. O.
By the methods of UV spectroscopy and theoretical conformational analyses was investigated the structural peculiarities of DNA at complexformation with cis-DDP at extremal pH medium (pH< 4, pH>9). It was shown that by ionization of nitrogen bases, significant changes in Tm(pH) and ΔT(pH) take place. However, DNA-cis-DDP bidental interstand crosslink model and formation of chelates does not play а prior role at the platination.
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