Effects of indomethacin on lipopolysaccharide-induced changes in some humoral factors of innate resistance and acid-base status in rats
2001
Andonova, M. | Slavov, E. | Spasova, V. (Trakian University - Faculty of Veterinary Medicine, Stara Zagora (Bulgaria))
Indomethacin, applied prior to LPS challenge prevented the negative effects of the agent to a certain extent. This drug influenced favorably the humoral factors of innate resistance - lysozyme, complement but could not restore the impaired liver function. Through its regulatory effec upon the respiratory component of acid-base status, it had some positive effect on LPS-induced decompensated metabolic acidosis.
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