Anti-oxidative and Cytoprotective Effect of Ursodeoxycholic Acid, an Active Compound from the Bear's Gall, in Mouse Microglia
2006
Joo, S.S. (Chung-Ang University, Seoul, Republic of Korea) | Kim, S.K. (Chung-Ang University, Seoul, Republic of Korea) | Yoo, Y.M. (Sangji University, Wonju, Republic of Korea) | Ryu, I.W. (Kangwon National University, Chuncheon, Republic of Korea) | Kim, S.H. (Kangwon National University, Chuncheon, Republic of Korea) | Lee, D.I. (Chung-Ang University, Seoul, Republic of Korea), E-mail: [email protected]
The in vitro cytoprotective and anti-oxidative effects of ursodeoxycholic acid, a major active compound from bear's gall were investigated in mouse brain microglia. In the present study, we wished to scrutinize the potential role of UDCA as an anti-neurodegenerative agent in neurodegenerative disease such as Alzheimer's disease. This concept was supported by the multiple preliminary studies in which UDCA has an anti-inflammatory effect in microglial cells.
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