Influence of hypocalorie diet with supplemented biologically active substances with antioxidant activity on dynamics clinicometabolic parameters in type 2 diabetes mellitus
2009
Sharafetdinov, Kh.Kh. | Plotnikova, O.A. | Zykina, V.V. | Alekseeva, R.I. | Maltsev, G.Yu. | Kaganov, B.S., Russian Academy of Medical Sciences, Moscow (Russian Federation). Research and Development Inst. of Nutrition
The research involved 2 groups of patients suffering from 2-type pancreatic diabetes at the age of 56.7+-1.6 years old with disease duration of 6.9+-1.2 years. The basic group (BG) included 25 persons, the comparison group (CG)- - 15 persons. All the patients received standard diet reduced to 1500 kcal for 3 weeks. The BG patients additionally received a dietary supplement tableted green tea at a dose of 1.2 g/day. All the patients received usual medicated therapy. All the patients stood well hypocaloric diet, demonstrated positive dynamics of subjective well-being and appearance clinical symptoms. In BG and CG over the research period there was observed equally reduced body weight, body weight index and percentage of fat. In BG systolic blood pressure by 17.8%, diastolic – by 18.3%, in CG the pressure declined by 10.5 and 9.9%, respectively. In BG fasting glucose in venous blood reduced by 24.7%, in capillary blood – by 19.5%; in CG – by 19.7 and 16.1%. 40 min after breakfast sugar was lower than prior to treatment, in BF – by 44.9%, in CG – by 27.6%. In BG a decline of total cholesterol by 16.5%in serum was observed, and low density lipoprotein cholesterol – by 18%, triglycerides – by 25%. In CG only total cholesterol reduced by 12.6%. Initially increased diene conjugates and malondialdehyde in serum in BG reduced by 18.2% and 145.7%, in CG – diene conjugates reduced by 21%, malondialdehyde –increased by 14.1%. In BG the activity of superoxide dismutase in erythrocytes by 11.2%, and glutathione peroxidase – by 12.4%. It is concluded about positive influence of tableted green tea on the patients suffering from pancreatic diabetes.
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