Effects of apparatus on age-related impairement of novel-object recognition in Kunming mice | 装置影响昆明小鼠物体再认记忆
2009
Wang Chao, the Affiliated Hospital of Anhui Medical University, Hefei(China), Department of Neurology | Jiang Wei, the Affiliated Hospital of Anhui Medical University, Hefei(China), Department of Neurology | Huang Dewu, Anhui Medical University, Hefei(China), Experimental Animal Center
Chinese. 在3种试验装置（Y形、方形及矩形）中检测昆明小鼠新物体再认能力的年龄及性别效应。结果表明，10min延迟试验中3个装置都没有检测到年龄和性别差异；24h延迟试验中21月龄鼠较6月龄和12月龄鼠新物体再认能力下降，且主要归因于雌鼠，Y形装置检测的数据较其他2个装置更敏感和稳定。以上结果提示，老年昆明雌鼠有遥远新物体再认记忆减退，Y形装置最敏感。[著者文摘]
Show more [+] Less [-]English. The effects of different apparatus, i. e. , Y-shape, square and rectangle boxs, on age-related impairement of memory in novel-object recognition task in Kunming mice were explored, respectively. The results indicated that there were no age-related changes in the 10-minute-delay trial in each of apparatus. During the 24 hours delay trial, the ability of novel-object recognition in the 21 -month mice decreased in the Y-shape box compared to the 6- month and 12-month mice, and in the square box compared to the 12-month mice,with being mainly attributable to females. The data measured in the Y-shape box were more stable than that in the others. These results suggested that there was age-related impairement of long-term memory of novel-object recognition in the female Kunming mice, and the Y-shape box was the suitable apparatus for detection of this impairement.
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