Biological activity of the newly synthesized D-seco and D-homoestratriene derivatives in in vivo and in vitro experiments. [Doctoral dissertation] | Biološka aktivnost novosintetisanih D-seko- i D-homo-estratrienskih derivata u in vivo i in vitro uslovima. Doktorska disertacija
2010
Jovanović-Šanta, S.
Some new compounds, 16- and 17-substituted 16,17-secoestratriene derivatives, as well as D-homoestratriene derivatives, were synthesized, starting from 3-benzyloxy-17-hydroxy-16,17-secoestra-1,3,5 (10)-triene-16-nitrile. The newly synthesized compounds were tested for their in vivo estrogenic and antiestrogenic activity, in vitro antiaromatase activity, antioxidative activity by DPPH and TBA tests, as well as antiproliferative activity against MCF-7 ATCC, MDA-MB-231, HT-29 and MRC-5 cell lines.
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