Study on effects of epigallocatechin gallate in tea on decreasing blood lipid of high-lipid rats | 茶叶中EGCG对高脂大鼠的降脂作用研究___
2011
Wang Xianbo, Hangzhou Institute of Agricultural Sciences, Hangzhou (China) | Zhou Jian, Chinese Academy of Agricultural Sciences, Hangzhou (China) | Cheng Hao, Chinese Academy of Agricultural Sciences, Hangzhou (China)
Chinese. ［目的］研究表没食子儿茶素没食子酸酯（EGCG）对高脂大鼠血脂调节作用。［方法］采用高脂大鼠模型，设正常对照组（Ⅰ组，喂基础饲料）、模型对照组（Ⅱ组，喂高脂饲料）、试验组（Ⅲ、Ⅳ组，喂高脂饲料，并每日分别灌喂0.5、1.0 g/kg的EGCG），连续喂饲30 d，测定其血清中TC、TG、HDL-C和LDL-C含量。［结果］Ⅲ、Ⅳ试验组TC、LDL-C含量极显著低于Ⅱ组（P0.01）；Ⅲ、Ⅳ组TG含量显著低于Ⅱ组（P0.05）；Ⅲ、Ⅳ组HDL-C含量较Ⅱ组变化不明显；Ⅳ组HDL-C含量略有升高，但差异不显著；Ⅲ、Ⅳ组_AI值_极显著低于Ⅱ组（P0.01）。［结论］EGCG具有降血脂作用。_
Show more [+] Less [-]English. ［Objective］To study the decreasing blood lipid effect of epigallocatechin gallate (EGCG) in high-lipid rats. ［Method］ Using high-lipid rats model, four groups were subdivided including normal CK (Ⅰ,feeding normal diet),model CK (Ⅱ,feeding high-fat diet) and test group (Ⅲ,Ⅳ,feeding high fat diet and giving EGCG of 0.5 and 1.0 g/kg, respectively). The rats in the four groups all were given for 30 d and were determined content of TC, TG, HDL-C and LDL-C in serum. ［Result］ Contents of TC and LDL-C in rats tested in group Ⅲ and Ⅳ were highly significantly lower than those in group Ⅱ (P0.01); TG in group Ⅲ and Ⅳ was significantly lower than that in group Ⅱ (P0.05). HDL-C in group Ⅲ and Ⅳ did not vary significantly in comparison with group Ⅱ and rats in group Ⅳ were a little higher in HDL-C. Compared with group Ⅱ,rats in group Ⅲ and Ⅳ were highly lower in AI value (P0.01). ［Conclusion］ EGCG is provided with effect of reducing blood lipid. _
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