Effect of Diets with Mulberry Leaf and Cudrania tricuspidataLeaf Powder Supplements on Blood Glucose-Related Biomarkers in Streptozotocin-Induced Diabetic Rats
2012
Park, J.H., Korea Food Research Institute, Seongnam, Republic of Korea | Lee, K.W., Korea Food Research Institute, Seongnam, Republic of Korea | Sung, K.S., Korea Food Research Institute, Seongnam, Republic of Korea | Kim, S.S., Korea Food Research Institute, Seongnam, Republic of Korea | Cho, K.D., Food One Tech Inc., Seoul, Republic of Korea | Lee, B.H., Chung-Ang University, Anseong, Republic of Korea | Han, C.K., Korea Food Research Institute, Seongnam, Republic of Korea
This study investigates the effects of diets with mulberry leaf and Cudrania tricuspidata leaf supplements on blood glucose-related biomarkers in streptozotocin-induced diabetic rats. Male diabetic Sprague-Dawley rats were divided into groups and fed several diets. Group A was fed a diet with a 10% supplement of mulberry leaves. Group B was fed a diet with a 10% supplement of mulberry leaves and an additional 10% supplement of Cudrania tricuspidata leaves. Group C was fed a diet with a 10% supplement of mulberry leaves and an additional 30% supplement of Cudrania tricuspidata leaves. Group D was fed a diet with a 10% supplement of Cudrania tricuspidataleaves. Group E was the DM control. All diets were based on AIN-93G diet and they all lasted 6 weeks. The blood glucose levels of groups B and C stayed similar to initial levels (reference blood glucose) for the experimental period, which was significantly lower than levels in groups A, D, and E at the 6th week (p less than 0.05). And the area under the blood glucose curve (AUC) was also significantly lower in groups B and C than in groups D and E (p less than 0.05). The fasting blood glucose level after the experiment was significantly lower in groups B and C (p less than 0.05), and the C-peptide content of group C was as high as 50 pmol/L on average. The HbA1c content was also significantly lower in groups A and B than in group E (p less than 0.05). The serum TG, AST, and ALT levels were significantly decreased in groups A, B, and D than in group E (p less than 0.05). From the findings, it is shown that a diet of 1:1 mulberry and Cudrania tricuspidataleaf supplements could improve blood glucose-related biomarkers.
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