Aluminum alters intracellular calcium homeostasis in vitro

Gandolfi, L.; Stella, M.P.; Zambenedetti, P.; Zatta, P.

Aluminum alters intracellular calcium homeostasis in vitro

1998

Gandolfi, L. | Stella, M.P. | Zambenedetti, P. | Zatta, P.

The present paper reports data regarding the influence of aluminum, at micromolar concentrations, on intracellular calcium homeostasis. Al3+ modifies Ca2+ uptake in the endoplasmic reticulum (ER), accelerates Ca2+ release from mitochondria and strongly inhibits Ca2+ -ATPase activity with a consequent high-level calcium accumulation inside the cell. These results suggest that Al3+ neurotoxicity may be related to an alteration of the intracellular calcium regulatory system.

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AGROVOC Keywords

active aluminum animals calcium calcium chemistry endoplasmic reticulum enzyme inhibitors enzymology homeostasis intracellular fluid liver metabolism mitochondria rats rats

Bibliographic information

Published in

Biochimica et biophysica acta = International journal of biochemistry and biophysics

Volume 1406 Issue 3 Pagination 315-320 - 320 ISSN 0006-3002

Publisher

Elsevier Inc.

Other Subjects

Calcium-transporting atpases; Alzheimer disease; Inorganic ions; Biological transport; Adenosinetriphosphatase; Organic chemicals; Wistar; Thapsigargin; Fluorescent dyes; Antagonists & inhibitors

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-28

Format: MODS

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Aluminum alters intracellular calcium homeostasis in vitro

1998

AGROVOC Keywords

Bibliographic information