Aluminum alters intracellular calcium homeostasis in vitro
1998
Gandolfi, L. | Stella, M.P. | Zambenedetti, P. | Zatta, P.
The present paper reports data regarding the influence of aluminum, at micromolar concentrations, on intracellular calcium homeostasis. Al3+ modifies Ca2+ uptake in the endoplasmic reticulum (ER), accelerates Ca2+ release from mitochondria and strongly inhibits Ca2+ -ATPase activity with a consequent high-level calcium accumulation inside the cell. These results suggest that Al3+ neurotoxicity may be related to an alteration of the intracellular calcium regulatory system.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
卷
1406
期
3
页码
315-320
- 320
ISSN
0006-3002
出版者
Elsevier Inc.
其它主题
Inorganic ions; Thapsigargin; Calcium-transporting atpases; Wistar; Fluorescent dyes; Biological transport; Adenosinetriphosphatase; Alzheimer disease; Antagonists & inhibitors; Organic chemicals
语言
英语
类型
Journal Article; Text
2024-02-28
MODS