Effect of an antithyroid agent (propylthiouracil) and L-ascorbic acid on mixed-function oxidase and drug metabolism in hepatic microsomes of chickens
1992
Takahashi, K. | Akiba, Y. | Horiguchi, M.
The experiments were undertaken to determine if an antithyroid agent (propylthiouracil, PTU) and/or ascorbic acid (AA) affect mixed-function oxidase (MFO) in hepatic microsomes of male broiler chicks. Feeding PTU increased the MFO activity in a dose-related manner. Addition of AA to the PTU-containing diet further increased the content of cytochromes P-450 and b 5, but not the activities of NADPH-cytochrome c and NADH-cytochrome b 5 reductase, and the drug-metabolizing enzymes. Supplemental AA induced cytochrome b 5 rather than cytochrome P-450.
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