Effect of an antithyroid agent (propylthiouracil) and L-ascorbic acid on mixed-function oxidase and drug metabolism in hepatic microsomes of chickens
1992
Takahashi, K. | Akiba, Y. | Horiguchi, M.
The experiments were undertaken to determine if an antithyroid agent (propylthiouracil, PTU) and/or ascorbic acid (AA) affect mixed-function oxidase (MFO) in hepatic microsomes of male broiler chicks. Feeding PTU increased the MFO activity in a dose-related manner. Addition of AA to the PTU-containing diet further increased the content of cytochromes P-450 and b 5, but not the activities of NADPH-cytochrome c and NADH-cytochrome b 5 reductase, and the drug-metabolizing enzymes. Supplemental AA induced cytochrome b 5 rather than cytochrome P-450.
显示更多 [+] 显示较少 [-]AGROVOC关键词
书目信息
出版者
Cambridge University Press
其它主题
Mixed function oxygenases; Antithyroid agents; Aminopyrine demethylation; Cytochrome p-450; Mixed function oxidase; Dose response; Nadph-cytochrome-c2 reductase; Propylthiouracil; Aniline hydroxylation; Nadh-cytochrome b5 reductase; Male; Drug metabolism; Drug effects
语言
英语
注释
2019-12-05
类型
Journal Article; Text
2024-02-28
MODS