Analgesic effect of Dioclea grandiflora constituents in rodents

Batista, J.S.; Almeida, R.N.; Bhattacharyya, J.

Analgesic effect of Dioclea grandiflora constituents in rodents

1995

Batista, J.S. | Almeida, R.N. | Bhattacharyya, J.

An aqueous fraction and dioclein (5,2',5'-trihydroxy-6,7-dimethoxyflavanone) obtained from the ethanolic extract of the Dioclea grandiflora were tested for their analgesic effect in mice and rats employing acetic-induced writhing and tail flick tests, respectively. When administered intraperitoneally the two agents exhibited significant analgesic effects. The activity of both dioclein and aqueous fraction apparently involves an opiate-like mechanism, since their analgesic action was attenuated by naloxone pretreatment.

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AGROVOC Keywords

acetates acetic acid analgesics analgesics animals chemistry drug therapy ethanol fabaceae flavonoids mice mice pain pharmacology plant extracts plant extracts rats rats rats toxicity

Bibliographic information

Published in

Journal of ethnopharmacology

Volume 45 Issue 3 Pagination 207 - 210 ISSN 0378-8741

Publisher

Dordrecht : Springer Netherlands

Other Subjects

Random allocation; Administration & dosage; Drug interactions; Drug; Dose-response relationship; Intraperitoneal; Injections; Therapeutic use; Flavanones; Wistar; Chemical fractionation; Naloxone; Male

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-28

Format: MODS

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Analgesic effect of Dioclea grandiflora constituents in rodents

1995

AGROVOC Keywords

Bibliographic information