Analgesic effect of Dioclea grandiflora constituents in rodents
1995
Batista, J.S. | Almeida, R.N. | Bhattacharyya, J.
An aqueous fraction and dioclein (5,2',5'-trihydroxy-6,7-dimethoxyflavanone) obtained from the ethanolic extract of the Dioclea grandiflora were tested for their analgesic effect in mice and rats employing acetic-induced writhing and tail flick tests, respectively. When administered intraperitoneally the two agents exhibited significant analgesic effects. The activity of both dioclein and aqueous fraction apparently involves an opiate-like mechanism, since their analgesic action was attenuated by naloxone pretreatment.
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书目信息
Journal of ethnopharmacology
卷
45
期
3
页码
207
- 210
ISSN
0378-8741
出版者
Dordrecht : Springer Netherlands
其它主题
Random allocation; Administration & dosage; Drug interactions; Drug; Dose-response relationship; Intraperitoneal; Injections; Therapeutic use; Flavanones; Wistar; Chemical fractionation; Naloxone; Male
语言
英语
类型
Journal Article; Text
2024-02-28
MODS