Acetogenins from Annonaceae, inhibitors of mitochondrial complex I

Zafra-Polo, M.C.; Gonzalez, M.C.; Estornell, E.; Sahpaz, S.; Cortes, D.

Acetogenins from Annonaceae, inhibitors of mitochondrial complex I

1996

Zafra-Polo, M.C. | Gonzalez, M.C. | Estornell, E. | Sahpaz, S. | Cortes, D.

One-hundred and twenty-eight different linear, epoxy, mono-tetrahydrofuran, bis-tetrahydrofuran or tri-tetrahydrofuran acetogenins have been isolated from the Annonaceae. These new secondary metabolites are potent cytotoxic inhibitors of the mitochondrial NADH:ubiquinone oxidoreductase (complex I of the respiratory chain).

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AGROVOC Keywords

annonaceae chemical structure chemistry enzyme inhibitors enzyme inhibitors enzymology furans furans lactones literature reviews mitochondria mitochondria oxidoreductases pharmacology plants plants respiration secondary metabolites

Bibliographic information

Published in

Phytochemistry

Volume 42 Issue 2 Pagination 253 - 271 ISSN 0031-9422

Other Subjects

Species specificity; Checklists; Medicinal; Derivatives; Isolation & purification; Ubiquinones; Nad (coenzyme); Molecular structure; Nad(p)h dehydrogenase (quinone); Molecular conformation; Antagonists & inhibitors; Chemical constituents of plants

Language

English

Note

2019-12-05

Type

Journal Article; Text

In AGRIS since: 2024-02-28

Format: MODS

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Acetogenins from Annonaceae, inhibitors of mitochondrial complex I

1996

AGROVOC Keywords

Bibliographic information