Vitamin K-dependent coagulation factors in gram-negative septicemia

Corrigan, James J. Jr

Vitamin K-dependent coagulation factors in gram-negative septicemia

1984

Corrigan, James J. Jr

Measurement of partial thromboplastin times (PTT) and prothrombin times (PT) in 16 children with gram-negative septicemia (Meningococcus, Hemophilus influenzae, Pseudomonas, Klebsiella-Aerobacter, and Salmonella) revealed that 10 of the children had abnormal PTT and PT values, due to a reduction in vitamin K-dependent coagulation factors. These abnormal coagulation results were not specific for disseminated intravascular coagulation (DIC) (a well-known compilation of gram-negative septicemia in humans); a significant number of the children had a non-DIC coagulopathy. Evidence was found that indicated that an endotoxin may interfere with the vitamin K carboxylation reaction. (wz)

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AGROVOC Keywords

analysis blood coagulation disorders children clinical trials coagulation etiology gram-negative bacteria humans physiology vitamin k vitamin k

Bibliographic information

Published in

American journal of diseases of children

Volume 138 Issue 3 Pagination 240 - 242 ISSN 0002-922X

Other Subjects

Blood coagulation factors; Hematologic diseases; Hematologic tests; Child; Sepsis; Preschool; Child; Vitamin k deficiency; Vitamin metabolism; Complications

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-28

Format: MODS

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Vitamin K-dependent coagulation factors in gram-negative septicemia

1984

AGROVOC Keywords

Bibliographic information