Biological effects of staphylococcal protein A immunotherapy in cats with induced feline leukemia virus infection

Lafrado, L.J.; Mathes, L.E.; Zack, P.M.; Olsen, R.G.

Biological effects of staphylococcal protein A immunotherapy in cats with induced feline leukemia virus infection

1990

Lafrado, L.J. | Mathes, L.E. | Zack, P.M. | Olsen, R.G.

Biological effects of staphylococcal protein A (SPA) immunotherapy were studied in 5 viremic and 6 nonviremic cats with induced FeLV infection and in 6 control cats. The SPA therapy neither reversed FeLV viremia nor resulted in consistent improvement in humoral immune responses to FELV antigens. However, SPA immunotherapy induced a proliferative response in bone marrow granulocytic lineage, possibly resulting in expression of FeLV-free mature neutrophils in the blood. Seemingly, viral burden and chemiluminescent responses were reversed in viremic cats during SPA immunotherapy.

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AGROVOC Keywords

animals cats cats chemiluminescence etiology feline oncovirus humoral immunity interferons leukemia leukemia neutrophils neutrophils physiology single cell protein therapy viremia

Bibliographic information

Published in

American journal of veterinary research

Volume 51 Issue 3 Pagination 482 - 486 ISSN 0002-9645

Other Subjects

Random allocation; Therapeutic use; Experimental; Female; Therapeutics; Feline; Leukemia virus; Staphylococcal protein a; Male; Specific pathogen-free organisms; Veterinary; Cat diseases

Language

English

Type

Text; Journal Article

In AGRIS since: 2024-02-28

Format: MODS

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