Biological effects of staphylococcal protein A immunotherapy in cats with induced feline leukemia virus infection

Lafrado, L.J.; Mathes, L.E.; Zack, P.M.; Olsen, R.G.

Biological effects of staphylococcal protein A immunotherapy in cats with induced feline leukemia virus infection

1990

Lafrado, L.J. | Mathes, L.E. | Zack, P.M. | Olsen, R.G.

Biological effects of staphylococcal protein A (SPA) immunotherapy were studied in 5 viremic and 6 nonviremic cats with induced FeLV infection and in 6 control cats. The SPA therapy neither reversed FeLV viremia nor resulted in consistent improvement in humoral immune responses to FELV antigens. However, SPA immunotherapy induced a proliferative response in bone marrow granulocytic lineage, possibly resulting in expression of FeLV-free mature neutrophils in the blood. Seemingly, viral burden and chemiluminescent responses were reversed in viremic cats during SPA immunotherapy.

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Ключевые слова АГРОВОК

animals cats cats chemiluminescence etiology feline oncovirus humoral immunity interferons leukemia leukemia neutrophils neutrophils physiology single cell protein therapy viremia

Библиографическая информация

Опубликовано в

American journal of veterinary research

Том 51 Выпуск 3 Нумерация страниц 482 - 486 ISSN 0002-9645

Другие темы

Random allocation; Therapeutic use; Experimental; Female; Therapeutics; Feline; Leukemia virus; Staphylococcal protein a; Male; Specific pathogen-free organisms; Veterinary; Cat diseases

Язык

Английский

Тип

Text; Journal Article

В АГРИСе с: 2024-02-28

Формат: MODS

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