Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste

Xu, Xijin; Yekeen, Taofeek Akangbe; Xiao, Qiongna; Wang, Yuangping; Lu, Fangfang; Huo, Xia

Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste

2013

Electronic waste recycling produces Polycyclic Aromatic Hydrocarbons (PAHs) and Polybrominated Diphenyl Ethers (PBDEs) which may affect fetal growth and development by altering the insulin-like-growth factor (IGF) system. Questionnaires were administered to pregnant women (Guiyu, an e-waste site, n = 101; control, n = 53), and umbilical cord blood (UCB) and placentas were collected upon delivery. PBDEs and PAHs in UCB and placental IGF-1 and IGFBP-3 mRNA levels were analyzed using GC–MS and real-time PCR, respectively. Infant birth length and Apgar scores were lower in Guiyu. All PAHs (except Fl, Chr, IP, BbF and BP), total 16-PAHs, total/individual PBDEs, placental IGF-1 (median 0.23 vs 0.19; P < 0.05) and IGFBP-3 (median 1.91 vs 0.68; P < 0.001) levels were significantly higher in Guiyu. Spearman correlation showed that BDE-154, BDE-209 and ∑5ring-PAHs positively correlate with IGF-1 while PBDEs, 4 rings and total PAHs correlate with IGFBP-3 expression. Increased placental IGF-1 level might indirectly affect fetal growth and development.

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AGROVOC Keywords

blood electronic wastes environmental monitoring fetal development fetus gas chromatography gestation growth humans mass spectrometry messenger rna metabolism methods placenta polycyclic aromatic hydrocarbons polycyclic aromatic hydrocarbons pregnancy pregnant women quantitative polymerase chain reaction questionnaires recycling rna toxicity

Bibliographic information

Published in

Environmental pollution

Volume 182 Pagination 63-69 - 69 ISSN 0269-7491

Publisher

The Indian Society of Dryland Agriculture

Other Subjects

Messenger; Umbilical cord; Insulin-like growth factor i; Prenatal; Electronic waste; Maternal exposure; Polybrominated diphenyl ethers; E-waste; Adult; Halogenated diphenyl ethers; Female; Insulin-like growth factor i; Insulin-like growth factor binding protein 3; Fetal blood; Male; Environmental pollutants; Growth and development

Language

English

Type

Journal Article; Text

In AGRIS since: 2024-02-29

Format: MODS

Data Provider

This bibliographic record has been provided by National Agricultural Library

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Links

DOI http://dx.doi.org/10.1016/j.envpol.2013.07.005

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