Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste

Xu, Xijin; Yekeen, Taofeek Akangbe; Xiao, Qiongna; Wang, Yuangping; Lu, Fangfang; Huo, Xia

Placental IGF-1 and IGFBP-3 expression correlate with umbilical cord blood PAH and PBDE levels from prenatal exposure to electronic waste

2013

Electronic waste recycling produces Polycyclic Aromatic Hydrocarbons (PAHs) and Polybrominated Diphenyl Ethers (PBDEs) which may affect fetal growth and development by altering the insulin-like-growth factor (IGF) system. Questionnaires were administered to pregnant women (Guiyu, an e-waste site, n = 101; control, n = 53), and umbilical cord blood (UCB) and placentas were collected upon delivery. PBDEs and PAHs in UCB and placental IGF-1 and IGFBP-3 mRNA levels were analyzed using GC–MS and real-time PCR, respectively. Infant birth length and Apgar scores were lower in Guiyu. All PAHs (except Fl, Chr, IP, BbF and BP), total 16-PAHs, total/individual PBDEs, placental IGF-1 (median 0.23 vs 0.19; P < 0.05) and IGFBP-3 (median 1.91 vs 0.68; P < 0.001) levels were significantly higher in Guiyu. Spearman correlation showed that BDE-154, BDE-209 and ∑5ring-PAHs positively correlate with IGF-1 while PBDEs, 4 rings and total PAHs correlate with IGFBP-3 expression. Increased placental IGF-1 level might indirectly affect fetal growth and development.

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Mots clés AGROVOC

blood electronic wastes environmental monitoring fetal development fetus gas chromatography gestation growth humans mass spectrometry messenger rna metabolism methods placenta polycyclic aromatic hydrocarbons polycyclic aromatic hydrocarbons pregnancy pregnant women quantitative polymerase chain reaction questionnaires recycling rna toxicity

Informations bibliographiques

Publié dans

Environmental pollution

Volume 182 Pagination 63-69 - 69 ISSN 0269-7491

Editeur

The Indian Society of Dryland Agriculture

D'autres materias

Prenatal; Female; Insulin-like growth factor i; Insulin-like growth factor binding protein 3; E-waste; Growth and development; Electronic waste; Insulin-like growth factor i; Maternal exposure; Environmental pollutants; Umbilical cord; Fetal blood; Adult; Messenger; Halogenated diphenyl ethers; Polybrominated diphenyl ethers; Male

Langue

anglais

Type

Journal Article; Text

Sur AGRIS depuis: 2024-02-29

Format: MODS

Fournisseur de données

Cette notice bibliographique a été fournie par National Agricultural Library

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Liens

DOI DOI http://dx.doi.org/10.1016/j.envpol.2013.07.005

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