Safety and efficacy of an attenuated strain of Salmonella choleraesuis for vaccination of swine

Kramer, T.T.; Roof, M.B.; Matheson, R.R.

Safety and efficacy of an attenuated strain of Salmonella choleraesuis for vaccination of swine

1992

Kramer, T.T. | Roof, M.B. | Matheson, R.R.

The purpose of this study was to determine the safety and efficacy of a live Salmonella choleraesuis immunizing strain, obtained by repeated ingestion and recovery through porcine neutrophils. The strain was tested in mice and in pigs. The vaccine was safe and effective in controlled experimental trials, using clinical, pathologic, and microbiologic criteria. Vaccinated pigs were able to maintain normal weight gains during the 4-week observation period following challenge inoculation with a high dose of a virulent strain.

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AGROVOC Keywords

animal animals attenuation body temperature body weight disease prevention immunology live vaccines mice mice microbiology pathogenicity salmonella salmonella choleraesuis spleen swine swine vaccination vaccination vaccines virulence

Bibliographic information

Published in

American journal of veterinary research

ISSN 0002-9645

Publisher

The Royal Society of Chemistry

Other Subjects

Dose-response relationship; Immunologic; Prevention & control; Attenuated; Adverse effects; Swine diseases; Veterinary; Human health and safety; Salmonella enterica; Salmonella infections; Female; Bacterial vaccines

Language

English

Note

2019-12-04

Type

Journal Article; Text

In AGRIS since: 2024-02-29

Format: MODS

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