Definition of quality parameters and chemical composition of feeds, evaluation their nutritional value and composing on this basis optimal rations for high productive animals are the most significant conditions for their health and production. More often metabolism disorders registers in the conditions of intensive animal production, at high dairy efficiency and intensive fattening. At animals at disorder of key parameters of technology (unbalanced feeding, hypodynamia, lack of insolation) is broken metabolism, decreases natural resistance, goes down quality of production that conducts to disease, premature culling and to the compelled slaughter of animals. On frequency these diseases occupy on the average 10% from all noncontagious diseases, and on dairy complexes with industrial technology and in specialized feeding economy at intensive cultivation on their share it is necessary over 30% of a noncontagious pathology. Today the control of rations on such indicators, as dry matter level, quantity of exchange energy, the maintenance of a crude and digested protein, amino acids, sugars, starch, cellulose, fat, macro-and microelements, vitamins, and also sugar-energy-protein and calcium-phosphoric parities, acid-base balance has got special value. The lack of those or other nutrients causes infringement of a clinical condition of animals and reduces their efficiency. Among the most widespread diseases of the animals registered in animal industry: cattle ketosis, osteodystrophy, endemic struma, hypomagnesiemia tetany, pasturable tetany, microelementosis, hypovitaminoses A and Е.

In the conditions of the Republic of Belarus there was produced a trial series of hyperimmune serum against livestock animals colibacillosis and there was realized the quality control of the analysed biological preparation. Research results proved that the developed serum was sterile, safe and had high immunogenetic activity. In course of quality control there were considered the following indexes: determination of physiognomy, colour, presence of visually accessible particulate matters; determination of safety and harnfullness; determination of activity; determination of concentration of hydrogen ions; determination of sterility; determination of serum volume in consumption package. For serum production there were used strains E.coli O9, O78, O0, O117, O26, O139, O15, O41, O55, O115, O141, O8, K88, K99, F41, 987P. For the production of trial series there was realized cultivation of Escherichia on the special nutritive media. There used bulls as serum producers

Analysis of data on distribution of clinicopathologic symptoms of rhinotracheitis, parainfluenza-3, bovine viral diarrhoea, clamidiosis, rhinosyncytial virus, adenovirus diseases, rotaviral diseases, coronavirus infections of cattle, viral transmissible gastroenteritis, and respiratory reproductive syndrome of swine, rinderpest, rabies and Aujesky disease of agricultural animals in the conditions of the Republic of Belarus was realized. There were given descriptions of diagnostic tests and vaccines for disease prevention used in Belarus and other countries. Treatment regimen and methods and other elements of prophylaxis were presented. There was given an analysis of prophylactic efficiency of produced medicine drugs

Analysis of the epizootological situation in infectious diseases in the world and the Republic of Belarus was presented. The prevention and eradication control strategy of mentioned diseases in Belarus was defined. In Belarus there was stated no cases of special danger infectious diseases of cattle: bovine spongiform encephalopathy; highly pathogenic poultry flu; aphthous fever; since 1982 - Bang's disease; since 1980 - Newcastle disease; since 1999 – anthrax. Preventive maintenance of 30 infectious diseases was based on application of specific prophylaxis.

In the conditions of the Republic of Belarus there was developed a production technology and there were produced samples of lyophilizated live vaccine against Aujeszky's disease of swine which corresponded to all parameters of control. The vaccine had an expressed phylactic power, induced the development of long-lived immunity of vaccinated piglets.

Usage of biological preparation of high antibacterial activity allows to decrease the air pollution by bacteria of colon bacillus group at 25-100%, increase productivity at 17-67 g, safety – at 0,4%, resistance, protein metabolism, protein fractions and some other indices (lysozyme and betalysine activity, leucocytes, erythrocytes, hemoglobin, calcium, phosphorus, iron, magnesium, AST, ALT, urea, cholesterol, bilirubin and glucose)

Application of antiviral preparation Mixoferon for poultry is studied. It is established, that Mixoferon application does not influence negatively on organism of hens, increases intensivity of protein metabolism, including the maintenance of antibodies in blood whey. Mixoferon in dozes of 2,5 ml (500000 МЕ), 1,5 ml (300000 МЕ), 0,5 ml (100000 МЕ) can be used for preventive maintenance and therapy of virus infections of hens

For the well-timed prevention and treatment of sick animals there was analyzed the therapeutic efficiency of a produced survivor serum against acute respiratory diseases of sheep and lambs, as well as Catosal in combination with Nitox 200 against the mixed flow of parainfluenza-3, adenovirus, respiratory syncytial, chiamydial and pasteurellosis infection. Comparative efficiency of all mentioned preparations was presented. Research results showed the correct and timely application of drug preparations as well as their qualitative selection made it possible to lower the death cases. Application of the presented survivor serum in combination with Nitox 200 and Catosal made it possible to lower the loss of cattle in 4-5 times and increase the viability rate of animals

In the conditions of the Republic of Belarus clinic and production conditions there was analyzed the prophylactic and therapeutic efficacy of a new national complex iron dextrane preparation Ferovital against deficiency (nutritional) anemia of new-born cattle and swine. In course of the study there were analyzed results of hematological and biochemical tests of blood of piglets which were administrated with Ferovital preparation. There were also marked the general economic index: live weight gain, disease incidence, piglet death rate, etc. Research results showed that the Ferovital preparation had an expressed prophylactic and therapeutic efficacy both in clinic and production conditions.

In the conditions of the Republic of Belarus there was determined the influence of lactulose of the clinical state of weanling piglets, as well as analysis of its preventive and therapeutic efficacy. For the experimental group of piglets in course of 5 days before weaning the lactulose for administrated daily in combination with feed in course of 5 days in dose of 0,002 gram per kilogram of live weight. In 3-5 days after weaning the diarrhea was stated in 4,1% of experimental piglets. The clinically evident efficiency of application of the synthetic disaccharide was showed in lowering of disbacteriosis level in weaning piglets on 33,7%. Besides, there was analyzed the therapeutic efficacy of lactulose for weaning piglets diseased with gastroenteritis. They were administrated lactulose in dose of 0,03 grams per kilogram of live weight once a day after feeding in course of 7 days. Haematologic and biochemical blood indexes of experimental and control groups of piglets were analyzed. Research results showed that application of lactulose promoted the creation of optimal conditions for beneficial microflora, stimulated its reproduction, suppressed the development of opportunistic pathogens.