In the conditions of the Republic of Belarus there was analyzed the influence of mycotoxins on state of energy metabolism and development of energy deficient states of bred and milking sows maintained in the production breeding conditions. Clinical status of sows was characterized by concurrent mycotoxicoses. As a result of action of mycotoxins in sows there was developed an energy deficiency and state of acidosis. The mentioned above changes played an important part in the pathogenesis of mycotoxicosis. There were presented the following results: analysis of groups of pregnant sows and suckling-pigs; the content of mycotoxins in mixed fodders; symptoms revealed at sows and pigs; indexes of carbohydrate and lipide exchanges in blood of sows; the content of trace elements in blood of sows; gas composition of sow blood. | Исследования проведены на супоросных и подсосных свиноматках, содержащихся в условиях промышленной технологии. Клинический статус свиноматок характеризовался сочетанным микотоксикозом. В результате действия микотоксинов у свиноматок развились энергодефицит и состояние ацидоза. Данные изменения являются важной составной частью патогенеза при микотоксикозах. В табличной форме представлены группы супоросных и подсосных свиноматок, содержание микотоксинов в комбикормах, симптомы, выявленные у свиноматок и поросят, показатели углеводного и липидного обменов в крови свиноматок, содержание макроэлементов в крови свиноматок, газовый состав крови свиноматок.

Investigation of method of gastroenteritis treatment of stores by means of application of enterosorbents was realized in the conditions of the Republic of Belarus. For the experiment there was used preparation Lactofiltrum containing 80% of hydrolyzed lignin and 20% of lactulose applied in dose of 0,3 g/kg once a day during 7 days. Efficiency of application of Lactofiltrum was compared with enterosorbent SV-2, which contained alcaline hydrolyzed lignin applied in dose of 1 g/kg once a day during 7 days. Four experimental groups piglets sick with gastroenteritis in the age of 1,5-2 months, with body weight of 15-17 kg were used in the experiment. The first group piglets were entered 0,3 g/kg body mass of Lactofiltrum once a day during 7 days. The second group piglets were entered enterosorbent SV-2 in dose of 1 g/kg in course of 7 days. For the piglets of the third group there was applied the complex of analysed preparations in same course of treatment. The fourth group of piglets was entered enrotim 10% in dose of 1 ml/ 20 kg of body mass. All animals had the same conditions of feeding and keeping. Research results showed that application of Lactofiltrum, SV-2 and their complex provided high antioxidative, detoxification, gepathoprotective activities. These preparations proved to be effective means of pathogenetic therapy for the treatment of gastroenteritis of piglets, both as individual preparations, and complex application. Comparative estimation of treatment methods of gastroenteritis showed that these preparations (except enrotim 10%) made it possible to regulate the metabolic processes due to elimination of intoxication, positive influence on hematopoiesis. The preparations lowered the duration of clinic manifestation of a disease and facilitated its duration, had gepathoprotective and antioxidative activity

There was estimated the indogenic intoxication development in animal, experimentally affected with larval cestodoses and its influence on meat quality. In the tabular form the indicators of farm animal parasitizing with larval cestodoses are presented; development indicators of endogenic intoxications of sheep parasitized with cysticercus; development indicators of endogenic intoxications of the rats parasitized with echinococcus larvacyst; dynamics of hematological indicators at sheep, experimentally infected with eggs Т Hydatigena; dynamics of hematological indicators of the laboratory rats experimentally infected with eggs Е granulosus; organoleptic meat characteristics of healthy sheep and sheep which affected with С Tenuicollis; biological value of sheep meat. As a result of the spent research it is revealed, that parasitizing of larval cestodoses at farm animals is accompanied by development of endogenic intoxications and as consequence considerably reduces quality of meat production. | Цель работы заключалась в оценке развития эндогенной интоксикации у животных, экспериментально инвазированных яйцами тениид, и ее влияния на качество получаемой мясной продукции. В табличной форме представлены показатели пораженности сельскохозяйственных животных личиночными формами цестод; показатели развития эндогенной интоксикации овец, пораженных цистицерками тенуикольными; показатели развития эндогенной интоксикации крыс, пораженных ларвоцистами эхинококка; динамика гематологических показателей у овец, экспериментально инвазированных яйцами Т. Hydatigena; динамика гематологических показателей лабораторных крыс, экспериментально зараженных яйцами Е. granulosus; органолептические показатели мяса овец здоровых и пораженных С. Tenuicollis; биологическая ценность мяса овец. В результате проведенных исследований выявлено, что паразитирование личиночных форм цестод у сельскохозяйственных животных сопровождается развитием эндогенной интоксикации и как следствие значительно снижает качество мясной продукции.

In the conditions of the Republic of Belarus there was realized clinical, biochemical, pathological-anatomical and histologic analysis of the efficiency of the national Tsinkovet (Zincovet) preparation doses in cases of experimental liver dystrophy caused by tetrachloromethane of white mice. For the modeling of toxic hepato-dystrophy there was applied tetrachloride carbon. Five tested and 2 controlled groups of scrub white mice were prepared. There were 23-29 mice in each group. Weight of mouse was 18 – 20 g. Conditions of feeding and keeping were the same in each group. 181 mice were used in the test. 5 ml/ kg of carbon tetrachloride was entered subdermal to tested group and the first controlled group mice once a day two days along. Tested dozes were estimated based on preparation toxicity. Maximum doze was 3 mg in 0,5 ml of distilled water for one mouse (1-st group - 3 mg, 2-nd group - 2, 75 mg, 4-th group - 2, 25 mg and 5-th group - 2 mg). Mice mortality was noticed during the experiment. Results of influence of different doses of the studied preparation on liver specific weight and variations of body mass were presented. Activity of amplifiers (succinate dehydrogenase (SDH), glutamate dehydrogenase (GLDH), aspartate aminotransferase (GOT), alanine-aminotransferase (GPT) in blood serum of mice after administration of tetrachloromethane and Tsinkovet preparation was analyzed. Drawings of liver acinus of hepatic steatosis were given. Research results proved that the analyzed zinc containing preparation substantially lowered the toxic action of tetrachloromethane and promoted the regeneration of liver cells