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Effects of ivermectin and fenbendazole in strategic treatment of gastrointestinal nematode infections in cattle.
1990
Williams J.C. | Knox J.W. | Barras S.A. | Hawkins J.A.
Four groups of 18 beef calves each were used to evaluate effects of different treatments on parasite control and weight gains. The investigation extended from November 1986 (weaning) to October 1987. Group-1 calves were treated with ivermectin (200 micrograms/kg of body weight, SC) at approximately 6-week intervals for a total of 8 treatments; group-2 calves were given the same dosage of ivermectin by the same route of administration as group-1 calves in November, March, and July; group-3 calves were given fenbendazole paste (5 mg/kg, PO) at the same times as group-2 calves; and group-4 calves served as untreated controls with provision for ivermectin salvage treatment. All groups grazed on individual pairs of larval-contaminated, 1.6-ha pastures. Highest (P < 0.05) initial worm counts in fall tracer calves were found in group 3 (Ostertagia ostertagi and Trichostrongylus axei adults) and group 4 (O ostertagi and Haemonchus adults). Fecal egg counts of group-1 calves were low throughout the experiment and pasture larval counts remained negligible after July. Egg counts and larval counts of other groups remained higher into summer. Worm counts, including O ostertagi inhibited early fourth-stage larvae (EL4), were highest (P < 0.05) in groups-3 and -4 spring tracer calves; numbers of O ostertagi EL4 were similarly high in groups 2, 3, and 4; and T axei counts were highest (P < 0.05) in groups-3 and -4 yearlings slaughtered in spring. Liveweights of group-1 calves were greater (P < 0.05) than in other groups from March 2 to October, and by July 2, group-2 calves had a liveweight advantage over group-4 calves. Group-3 calves had the lowest rate of gain from March to July and mean liveweight of the group was less (P < 0.05) than in all other groups from April to October. Only minimal worm numbers were recovered from groups-1 or -2 calves in October. Large numbers of O ostertagi and T axei were recovered from group-4 calves and O ostertagi from group-3 calves. A few calves in groups 3 and 4, but 365 kg in group 1, 328 kg in group 2, 316 kg in group 4, and 281 kg in group 3.
Show more [+] Less [-]Immunologic factors related to survival and performance in neonatal swine.
1990
Tyler J.W. | Cullor J.S. | Thurmond M.C. | Douglas V.L. | Parker K.M.
Logistic regression was used to develop models predicting preweaning survival in 334 neonatal swine. Measured risk factors included birth weight, litter size (live born), dam parity, serum IgG concentration, serum ELISA titers recognizing common gram-negative core antigens, and serum concentrations of the third component of complement. Larger birth weights were associated with increased probability of preweaning survival. The highest mortality was observed in litters with more than 12 pigs. Pigs with serum concentration of the third component of complement (C3) in the lowest stratum, < 20% adult pooled C3 standard (APC3), had reduced mortality, compared with high (> 38% APC3) and middle (20 to 38% APC3) groups. Associations between all other variables, including total serum IgG concentration and preweaning survival were not significant. Few pigs had hypogammaglobulinemia, < 3% of the study population had serum IgG concentrations < 1 g/dl. Of all measured variables, only birth weight and dam parity were significant predictors of preweaning gain. Larger pigs and pigs born to third or greater parity dams had more preweaning gain than other pigs.
Show more [+] Less [-]Host determinants of pneumonia in slaughter weight swine
1990
Gardner, I.A. | Hird, D.W.
A prospective cohort study was undertaken in a farrow-to-farrow swine herd to describe patterns of pneumonia, and to identify host risk factors associated with the extent of pneumonic lesions in 2 weight groups of slaughter swine. The risk of coughing and pneumonic lesions increased with increasing age of pigs within the herd (P < 0.0001). The age-specific prevalence of pneumonic lesions was low (2.7%) in pigs < 16 weeks old at slaughter, but increased rapidly when pigs were between 16 and 22 weeks old (8.6 to 67.9%). After 22 weeks, the prevalence remained relatively constant at about 80%. Associations between possible risk factors and pneumonia were investigated by use of multiple-regression models. Age at weaning (< 24 days) and birth weight (< 1 kg) exerted small, but significant (P < 0.002), effects on the extent of pneumonic lesions in pigs slaughtered at 30 to 50 kg live weight. For pigs slaughtered at 90 to 110 kg, pneumonic lesions were more extensive (P = 0.007) in pigs sired by Yorkshire boars than pigs sired by non-Yorkshire sires (Duroc, Hampshire, Chester White, or American Spotted). Other host factor variables including weaning weight and clinical diseases (atrophic rhinitis, diarrhea, and arthritis) were not associated with pneumonia extent in either weight group. Higher pneumonia percentages were also associated with reduced growth rates in the grower/finisher phase. Pigs sired by Yorkshire boars grew significantly (P < 0.0001) more slowly from entry into shed 2 (mean, 38 kg) until about the time of exit (mean, 92 kg) than pigs sired by other breeds (747 g/d and 795 g/d, respectively).
Show more [+] Less [-]Protein requirements of growing pups fed practical dry-type diets containing mixed-protein sources
1990
Case, L.P. | Czarnecki-Maulden, G.L.
The protein requirement of Pointer pups fed practical diets was assessed in 3 experiments. Eight-week-old pups required 25.2% protein when fed a combination of corn gluten meal, soybean meal, and meat and bone meal for 2 weeks. However, when a poor-quality poultry by-product meal was substituted for some of the corn gluten meal and meat and bone meal, the requirement increased to 27.5%. This increased requirement was explained by decreased digestibility of the poultry by-product meal diet. Pups fed each of the diets required 18% digestible protein to maximize growth rate. Sixteen-week-old pups were more efficient at utilizing the experimental diets, requiring only 23% crude protein (17.2% digestible protein) to maximize growth rate.
Show more [+] Less [-]Physiologic and body composition changes in feeder pigs under simulated marketing conditions
1990
Becker, B.A.
Two experiments were conducted to determine changes in body composition and various physiologic variables in feeder pigs under simulated marketing conditions. In the first experiment, pigs were assigned to 1 of 4 treatment groups for 48 hours: (1) no water and feed; (2) water ad libitum, no feed; (3) no water, feed ad libitum; or (4) water and feed ad libitum. During a 48-hour recovery period, all pigs were allowed feed and water ad libitum. Plasma triiodothyronine decreased (P < 0.01) within the first 24 hours in groups-1 and -2 pigs, but increased (P < 0.01) within the first 6 hours of the recovery period. The circadian rhythm of plasma cortisol was disrupted in groups-1 and -3 pigs and during recovery in group-1 pigs. Packed cell volume increased (P < 0.05) in groups-1 and -3 pigs and returned to initial values within the first 24 hours of the recovery period. In the second experiment, body composition was estimated by the 40K technique for fat-free body mass, percentage of nitrogen, and percentage of fat. Body composition was determined before and after pigs were allotted to 1 of 2 groups for 48 hours: group-1 pigs were given feed and water ad libitum and group-2 pigs were not given feed and water. Group-1 pigs gained 2.2 kg of body weight (P < 0.01), 0.6% fat (P < 0.01), 0.7 kg of fat-free body mass, and 0.02% nitrogen (P > 0.01). Group-2 pigs lost 2.3 kg of body weight (P < 0.01), 0.6% fat (P < 0.01), 2.0 kg of fat-free body mass (P < 0.01), and 0% nitrogen.
Show more [+] Less [-]Effect of T-2 toxin on resistance to systemic Salmonella typhimurium infection of newly hatched chickens
1990
Ziprin, R.L. | Elissalde, M.H.
Newly hatched chickens were treated with the trichothecene mycotoxin, T-2 toxin, during the first day of life. Control chickens were treated with other agents known to cause immunosuppression-cyclosporine, cyclophosphamide, and aflatoxin. Chickens were infected on day 6 (5 days after treatment with T-2 toxin) by intraperitoneal inoculation with Salmonella typhimurium. Blood samples were collected from treated chickens (noninfected) and used to assess the responsiveness of blood lymphocytes to T-cell or B-cell mitogens, phytohemagglutinin, or lipopolysaccharide, respectively. The T-2 toxin had a profound negative effect on the ability of the chickens to resist salmonellosis, as measured by survival. However, the toxin effect in reducing phytohemagglutinin- and lipopolysaccharide-stimulated mitogenesis, though significant (P > 0.05), was not severe. Our data indicate a direct effect of T-2 toxin on native resistance to systemic salmonellosis, which was not accompanied by marked alteration in T- or B-cell responses to mitogenic stimulation.
Show more [+] Less [-]Effects of preweaning exposure to a starter diet on enterotoxigenic Escherichia coli-induced postweaning diarrhea in swine
1990
Sarmiento, J.I. | Runnels, P.L. | Moon, H.W.
Experiments were conducted to evaluate the effect of restricted feeding of a starter diet to suckling pigs (creep feeding) in a model of postweaning colibacillosis. The hypothesis that restricted creep feeding primes an intestinal allergic reaction to starter diet ingested after weaning was tested. Twenty-eight suckling pigs were fed a starter diet for 3 h/d on days 7, 8, and 9 after birth (creep-fed). Twenty-six suckling pigs were not fed the diet until 3 weeks of age (not creep-fed), when all pigs were weaned and given the starter diet. One day after weaning, 24 creep-fed and 22 not creep-fed pigs were inoculated with K88+ enterotoxigenic Escherichia coli, and 4 pigs in each group were kept as noninoculated controls. Among inoculated pigs (principals), 10 creep-fed and 12 not creep-fed pigs were found to be genetically resistant to K88+ E coli and remained healthy during the 6-day postinoculation period, as did the noninoculated controls. Eighteen (10 creep-fed and 8 not creep-fed) of the 24 genetically susceptible principals developed diarrhea after inoculation. There were no significant differences in the incidence and severity of diarrhea, amount of body weight loss, and mortality between creep-fed and not creep-fed susceptible principal pigs. Histologic examination of intestine from control pigs and principals that survived for 6 days after infection did not reveal any substantial morphologic difference between creep-fed and not creep-fed groups. In conclusion, creep feeding was not required for the production of diarrhea in this model. Creep feeding did not induce morphologic changes characteristic of an allergic reaction in the small intestine.
Show more [+] Less [-]Effects of treatment of growing swine with aflatoxin and T-2 toxin
1990
Harvey, R.B. | Kubena, L.F. | Huff, W.E. | Corrier, D.E. | Rottinghaus, G.E. | Phillips, T.D.
Effects of dietary aflatoxin (AF) and T-2 toxin, singly and in combination, were evaluated in growing crossbred (Yorkshire X Landrace X Hampshire) pigs. The experimental design consisted of 4 treatment groups of 6 barrows each fed diets containing 0 mg of AF and T-2/kg of feed (controls; group 1), 2.5 mg of AF/kg of feed (group 2), 10 mg of T-2/kg of feed (group 3), or 2.5 mg of AF plus 10 mg of T-2/kg of feed (AF + T-2; group 4) ad libitum for 28 days (7 to 11 weeks of age). Production performance, and serum biochemical, and hematologic evaluations were made weekly. Body weight and body weight gain were depressed by all toxin treatments, but the effect of AF and T-2 toxin in combination was less than additive. Liver and kidney weights, as a percentage of body weight, were increased by AF treatment, and heart weight, as a percentage of body weight, was increased by T-2 treatment. Treatment with T-2 toxin induced necrotizing contact dermatitis on the snout, buccal commissures, and prepuce. Consumption of AF resulted in increased serum activities of alkaline phosphatase, aspartate transaminase, cholinesterase, and gamma-glutamyltransferase, and decreased serum concentrations of urea nitrogen, cholesterol, albumin, total protein, calcium, potassium, magnesium, and phosphorus. Consumption of T-2 toxin resulted in increased serum triglyceride concentration and decreased serum iron concentration. Treatment with AF induced lower serum unsaturated iron-binding capacity and high RBC count, PCV, hemoglobin concentration, WBC count, and prothrombin time. Treatment with T-2 toxin induced microcytic hypochromic anemia, increased numbers of circulating metarubricytes and decreased absolute numbers of lymphocytes. Hepatocellular lesions in barrows of the AF and the AF plus T-2 groups (2 and 4, respectively) were compatible with aflatoxicosis. When fed in combination, each toxin appeared to have a sparing action on certain effects of the other, and the responses elicited were either additive or less than additive.
Show more [+] Less [-]Effect of administration with fat-free diet and dietary iron on polyunsaturated fatty acid, vitamin E and their derivatives in male rats
1990
Huh, R.S. | Kim, Y.H. | Do, J.C. | Lee, Y.H. | Choi, Y.S. (Kyungpook National University, Taegu (Korea Republic). College of Veterinary Medicine) | Kim, S.H. (Korea Research Institute of Chemical Technology, Taejon (Korea Republic))